Methods and compositions for inducing apoptosis in cancer cells

Details Methods and compositions for inducing apoptosis in cancer cells Methods and compositions for inducing apoptosis in cancer cells

2007-06-12

2007-06-12

Ungar, Susan (Department: 1642)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

Reexamination Certificate

active

10723383

ABSTRACT:
Anti-DR4 or Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells.

REFERENCES:
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Kipriyanov (1999, Molecular Biotechnology 12:173-201).
Bowie et al, Science, 247:1306-1310, 1990.
Gussow et al (Methods in Enzymology, 1991, 203:99-121).
Rudikoff et al, PNAS, USA, 1982, 79: 1979-1983.
Chuntharapai, Anan et al.; “Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4”;The Journal of Immunology, vol. 166, pp. 4891-4898.
Dong, Qiang G. et al.; “The function of multiple IkB: NF-kB complexes in the resistance of cancer cells to Taxol-induced apoptosis”; 2002,Oncogene, vol. 21, pp. 6510-6519.
Odoux, Christine et al.; “Trail, Fast and a Blocking Anti-DR5 Antibody Augment Paclitaxel-Induced Apoptosis in Human Non-Small-Cell”; 2002,Int. J. Cancer, vol. 97, pp. 458-465.

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