Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-05-20
1998-06-23
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 6, 435 15, 435 29, 435 32, 4351721, 4351723, 435 74, 436 63, 436 64, 436813, G01N 33574, G01N 33573, C12Q 100
Patent
active
057703868
ABSTRACT:
The invention provides a method of increasing the sensitivity of a cell to a DNA damaging agent comprising increasing the amount of an NM23 in the cell. The method is especially useful for increasing the sensitivity of tumor cells to chemotherapy and radiation.
REFERENCES:
patent: 5049662 (1991-09-01), Steeg et al.
Biggs et al., "A Drosophila Gene that is Homologous to a Mammalian Gene Associated with Tumor Metastasis Codes for Nucleoside Diphosphate Kinase," Cell 63:933-940 (1990).
Chu and Chang, "Xeroderma Pigmentosum Group E Cells Lack a Nuclear Factor that Binds to Damaged DNA," Science 242:564-567 (1988).
Chu and Chang, "Cisplatin-Resistant Cells Express Increased Levels of a Factor that Recognizes Damaged DNA," Proc. Natl. Acad. Sci. USA 87:3324-3327 (1990).
Leone et al., "Reduced Tumor Incidence, Metastatic Potential, and Cytokine Responsiveness of nm23-Transfected Melanoma Cells," Cell 65:25-35 (1991).
Patterson and Chu, "Evidence that Xeroderma Pigmentosum Cells from Complementation Group E are Deficient in a Homolog of Yeast Photolyase," Molecular and Cellular Biology 9:5105-5112 (1989).
Rosengard et al., "Reduced Nm23/Awd Protein in Tumour Metastasis and Aberrant Drosophila Development," Nature 342:177-180 (1989).
Stahl et al., "Identification of a Second Huan nm23 Gene, nm23-H2," Cancer Research 51:445-449 (1991).
Steeg et al., "Evidence for a Novel Gene Associated with Low Tumor Metastatic Potential," Journal of the National Cancer Institute 80:200-204 (1988).
Wallet et al., "Dictyostelium Nucleoside Diphosphate Kinase Highly Homologous to Nm23 and Awd Proteins Involved in Mammalian Tumor Metastasis and Drosophila Develoment," Journal of the National Cancer Institute 82:1199-1202 (1990).
Ghiorghis, A., et al., Proc. Annu Meet Am Assoc Cancer Res, vol. 32, Abstract No. A2567, 1991.
Flatow Ursula
Liotta Lance A.
Steeg Patricia S.
Scheiner Toni R.
The United States of America as represented by the Department of
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