Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-08-12
1999-10-12
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514561, A61K 31415, A61K 31195
Patent
active
059655968
ABSTRACT:
A method for increasing the synthesis and accumulation of beta-alanylhistidine dipeptides, with a simultaneous increase in the accumulation of creatine, in bodily tissues of humans and animals is described. This is accomplished by causing an increase in the blood plasma concentrations of beta-alanine and creatine, or the blood plasma concentrations of beta-alanine, L-histidine and creatine, by the ingestion or infusion of a composition including beta-alanine, beta-alanine and creatine, or beta-alanine, L-histidine and creatine, or active derivatives thereof.
REFERENCES:
Dunnett, Mark, Carnosine Metabolism and Function in the Thoroughbred Horse (Anaerobic Exercise), Dissertation (Open University), vol. 57/04-C of Dissertation Abstracts International, p. 1143, (1996).
Harris, et al., Muscle Buffering Capacity and Dipeptide Content in the Thoroughbred Horse, Greyhound Dog and Man, Comp. Biochem. Physiol., 97A(2):249-251, (1990).
Huszti, et al., "Effects of L-Histidine Administration on the Concentrations of Histidine in Various Tissues", Agents Actions, 4(3):183, Aug. (1974).
Nutzenadel, et al., "Uptake and metabolism of .beta.-alanine and L-carnosine by rat tissue in vitro; role in nutrition", Am. J. of Physiology, 230(3): 643-51, Mar. (1976).
Dunnett Mark
Harris Roger
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