Methods and compositions for increasing production of erythromyc

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4351723, 4352523, C12P 1962

Patent

active

059087641

ABSTRACT:
Methods and compositions for increasing the production of erythromycins are provided. In particular, the invention relates to the engineering of erythromycin-producing organisms to express a heterologous oxygen-binding protein.

REFERENCES:
patent: 5049493 (1991-09-01), Khosla et al.
patent: 5190871 (1993-03-01), Cox et al.
Emler et al., 1995, "Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 .ANG. resolution," The EMBO Journal 14(24):6067-6077.
Tarricone et al., 1997, "Unusual structure of the oxygen-binding site in the dimeric bacterial hemoglobin from Vitreoscilla sp.," Structure 5 (4):497-507.
Altenbuchner et al., 1992, Meth. Enzymol. 216:457-466.
Bevitt et al., 1992, Eur. J. Biochem. 204:39-49.
Bibb et al., 1986, Fifth International Symposium on the Genetics of Industrial Microorganisms, Zagreb, pp. 309-318.
Bierman et al., 1992, Gene 116:43-49.
Brunker et al., 1996, Mol. Gen. Genet. 251:307-315.
Clark et al., 1995, Microbiology 141:663-669.
Cortes et al., 1991, Nature 346:176-178.
Cramm et al., 1994, J. Biol. Chem. 269:7349-7354.
DeModena, J.A. et al., 1993, Bio/Technology 11:926-929.
Donadio and Hutchinson, 1991, Gene 100:231-235.
Donadio et al., 1991, Science 252:675-679.
Donadio et al., 1990, J. Bacteriol. 172:350-360.
Donadio et al., 1992, Gene 111:51-60.
Hanel et al., 1993, Biotech. Lett. 15:105-110.
Heydarian et al., 1996, Biotechnol. Letts. 18:1181-1186.
Hopwood et al., 1983, J. Gen. Microbiol. 129:2257-2269.
Horan et al., 1993, Abstract, Joint Mtg of Soc. for Industr. Microbiol. and Canad. Soc. of Microbiol., Jul. 31-Aug. 6, 1996, Toronto, Canada.
Kallio et al., 1994, Eur. J. Biochem. 219:201-208.
Kallio et al., 1996, Biotechnol. Prog. 12:31-39.
Kallio et al., 1996, Biotechnol. Prog. 12:751-757:.
Kao et al., 1994, Science 265:509-512.
Khosla and Zawada, 1996, Trends Biotechnol. 14:335-41.
Khosla and Bailey, 1988, Mol. Gen. Genet. 214:158-161.
Kieser and Hopwood, 1991, Meth. Enzymol. 204:430-458.
Kuhstoss et al., 1991, J. Mol. Biol. 222:897-908.
Lal et al., 1996, Crit. Rev. Microbiol. 22(4):201-255.
Magnolo, S.K. et al., 1991, Bio/Technology 9:473-476.
Martin et al., 1975, Tetrahedron 31:1985-1989.
Mazodier (1989), J. Bacteriol. 171:3583-3585.
McDaniel et al., 1995, Nature 375:533.
Motamedi et al., 1995, Gene 160:25-31.
Paulus et al., 1990, J. Bacteriol. 172:2541.
Rausch and Lehmann, 1991, Nucl. Acids Res. 19:5187-5189.
Smokvina et al., 1990, Gene 94:53-59.
Tsai et al., 1995, Biotechnol. Bioeng 47:347-354.
Tsai et al., 1996, Biotechnol. Bioeng. 49:151-160.
Tuan et al., 1990, Gene 90:21-29.
Wakabayashi et al., 1986, Nature 322:481-483.
Weber et al., 1985, J. Bacteriol. 164:425-433.
Weber et al., 1991, Science 252:114.
Zak et al., 1990, Eur. J. Clin. Mircorbiol. Infect. Dis. 9:462-465.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and compositions for increasing production of erythromyc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for increasing production of erythromyc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for increasing production of erythromyc will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-954571

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.