Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-07-19
2011-07-19
Shiao, Rei-tsang (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S256000
Reexamination Certificate
active
07981917
ABSTRACT:
The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering the release of histamine. Induction of apoptosis may be enhanced by first inducing or further aggravating ER-stress through inhibition of proteasome or proteases. Also provided are compounds and compositions useful as ER-stress aggravating agents, methods for screening, selecting, identifying and designing the same and methods for treating diseased conditions by inducing apoptosis through specific and selective aggravation of ER-stress.
REFERENCES:
patent: 5756530 (1998-05-01), Lee et al.
patent: 2004/0033934 (2004-02-01), Nichols et al.
patent: 2004/0156872 (2004-08-01), Bosch et al.
patent: 2007/0009593 (2007-01-01), Potter
patent: 2007/0010548 (2007-01-01), Drees et al.
Alex Schonthal “Antitumor Properties of Dimethyl-Celecoxib, a Derivative of Celecoxib That Does Not Inhibit Cyclooxygenase-2: Implications for Glioma Therapy” Neurosurg Focus vol. 20, No. 4, p. E21, 2006.
Zhu et al. “Using Cyclooxygenase-2 Inhibitors as Molecular Platforms to Develop a New Class of Apoptosis-Inducing Agents” Journal of the National Cancer Institute, vol. 94, No. 23, pp. 1745-1757, 2002.
Tsutsumi et al. “Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis” Cell Death and Differentiation vol. 11, pp. 1009-1016, 2004.
Johnson et al. “The cyclo-oxygenase-2 inhibitor celecoxib perturbs intracellular calcium by inhibiting endoplasmic reticulum Ca2+ATPases: a plausible link with its anti-tumour effect and cardiovascular risks” Biochem J. vol. 366, pp. 831-837, 2002.
Namba et al. “Up-Regulation of 150-kDA Oxygen-Regulated Protein by Celecoxib in Human Gastric Carcinorma Cells” Mol Pharmacol vol. 71, pp. 860-870, 2007.
International Search Report for corresponding PCT application PCT/US08/58323, 2008.
Chen Thomas C.
Hofman Florence M.
Louie Stan G.
Petasis Nicos A.
Schönthal Axel H.
DLA Piper (LLP) US
Shiao Rei-tsang
University of Southern California
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