Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof
Patent
1993-07-30
1998-10-13
Caputa, Anthony C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Cancer cell or component thereof
424 9371, 424534, 424577, 435 2, 514908, 604 4, 604 6, 604 20, 604 27, 604 28, A61K 3514, A61K 4100, A61K 4505
Patent
active
058208720
ABSTRACT:
Methods and pharmaceutical compositions for improving the effectiveness of radiation therapy for treating a subject having an internal solid tumor malignancy are disclosed. The methods include irradiating the tumor to release tumor-derived antigens in vivo, preparing a cellular vaccine including the isolated antigens admixed with a preparation of altered antigen presenting cells and administering the cellular vaccine to the subject. In the preferred embodiments, the antigen presenting cells are leukocytes that have been photochemically altered by subjecting the cells to photopheresis.
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Edelson Richard L.
Gasparro Francis P.
Caputa Anthony C.
Yale University
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