Methods and compositions for importing nucleic acids into...

Details Methods and compositions for importing nucleic acids into... Methods and compositions for importing nucleic acids into...

2005-07-15

2009-10-20

Hama, Joanne (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C536S023100, C435S005000

Reexamination Certificate

active

07604798

ABSTRACT:
The present invention relates to methods and compositions for importing DNA into the nuclei of a specific cell type. In particular, the present invention provides methods and compositions for specifically targeting the nuclei of pulmonary cells.

REFERENCES:
patent: 4650764 (1987-03-01), Temin et al.
patent: 4797368 (1989-01-01), Carter et al.
patent: 4861719 (1989-08-01), Miller
patent: 4980289 (1990-12-01), Temin et al.
patent: 5124263 (1992-06-01), Temin et al.
patent: 5139941 (1992-08-01), Muzyczka et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5459127 (1995-10-01), Felgner et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 453 242 (1991-04-01), None
patent: 178 220 (1992-01-01), None
patent: WO 89/07150 (1989-08-01), None
patent: WO 90/02806 (1990-03-01), None
patent: WO 91/18088 (1991-11-01), None
patent: WO 92/05263 (1992-04-01), None
patent: WO 93/09239 (1993-05-01), None
patent: WO 94/12649 (1994-06-01), None
patent: WO 94/21807 (1994-09-01), None
patent: WO 94/26914 (1994-11-01), None
patent: WO 94/28152 (1994-12-01), None
patent: WO 94/28938 (1994-12-01), None
patent: WO 95/02697 (1995-01-01), None
patent: WO 95/07358 (1995-03-01), None
patent: WO 95/18863 (1995-07-01), None
patent: WO 95/21931 (1995-08-01), None
patent: WO 96/17823 (1996-06-01), None
patent: WO 96/17823 (1996-07-01), None
patent: WO 96/22378 (1996-07-01), None
patent: WO 96/25508 (1996-08-01), None
patent: WO 97/34915 (1997-09-01), None
Cowan et al., 2003, Xenotransplantation, 10: 223-231.
Glasser et al., 2000, Am. J. Physiol. Lung Cell Mol. Physiol., 278: L933-L945.
Xu et al., 2000, Circulation Research, 87: 254-260.
Glasser et al., 1990, JBC, 265: 21986-21991.
SuperFect Transfection Reagent Handbook [online], 2002 [retrieved Apr. 10, 2008]. Retrieved from the Internet:<http://www1.qiagen.com/HB/SuperFectTransfectionReagent—EN, pp. 1-31.
Dowty et al., “Plasmid DNA Entry Into Postmitotic Nuclei of Primary Rat Myotubes,” PNAS 92:4572 (1995).
Samulski et al., “A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication,” J. Virol., 61:3096-3101 [1987].
Samulski et al., “Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression,” J. Virol., 63:3822-3828 [1989].
Markowitz et al., “A safe packaging line for gene transfer: separating viral genes on two different plasmids,” J. Virol., 62:1120 [1988].
Kuo et al., “Efficient gene transfer into primary murine lymphocytes obviating the need for drug selection,” Blood 82:845 [1993].
Bender et al., “Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region,” J. Virol., 61:1639 [1987].
Felgner et. al., Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure, Proc. Natl. Acad. Sci. USA 84:7413-7417 [1987].
Machey, et al., “Gene Transfer from Targeted Liposomes to Specific Lymphoid Cells by Electroporation,” Proc. Natl. Acad. Sci. USA 85:8027-8031 [1988].
Wilson et al., “Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor- deficient rabbits,” J. Biol. Chem., 267:963-967 [1992].
Wu and Wu, “Receptor-mediated gene delivery and expression in vivo ,” J. Biol. Chem., 263:14621-14624 [1988].
Williams et al., “Introduction of Foreign Genes into Tissues of Living Mice by DNA-Coated Microprojectiles,” Proc. Natl. Acad. Sci. USA 88:2726-2730 [1991].
Wu and Wu, “Receptor-mediated in vitro gene transformation by a soluble DNA carrier system [published erratum appears in J Biol Chem Jan. 5, 1988;263(1):588,” J. Biol. Chem., 262:4429-4432 [1987].
Dean, “Import of plasmid DNA into the nucleus is sequence specific,” Exp. Cell. Res. 230:293 (1997).
Miller and Rosman, “Improved REtroviral Vectors for Gene Transfer and Expression,” Biotechniques, 7:980-990 [1992].
Kaplitt et al., “Expression of a Functional Foreign Gene in Adult Mammalian Brain following in Vivo Transfer via a Herpes Simplex Virus Type 1 Defective Viral Vector,” Mol. Cell. Neurosci., 2:320-330 [1991].
Stratford-Perricaudet et al., Widespread long-term gene transfer to mouse skeletal muscles and heart, J. Clin. Invest., 90:626-630 [1992].
La Salle et al., “An Adenovirus Vector For Gene Transfer into Neurons and Glia in the Brain,” Science 259:988-990 [1993].
Lebkowski et al., “Adeno-associated virus: a vector system for efficient introduction and integration of DNA into a variety of mammalian cell types,” Mol. Cell. Biol., 8:3988-3996 [1988].
Mav1, “Transcription Mapping of Mouse Adenovirus Type 1 Early REgion 3,” Beard et al., Virol., 75-81 [1990].
Levrero et al., “Defective and nondefective adenovirus vectors for expressing foreign genes in vitro and in vivo,” Gene 101:195 [1991].
Graham, “Covalently closed circles of human adenovirus DNA are infectious,” EMBO J., 3:2917 [1984].
Mann et al., “Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus,” Cell 33:153 [1983].
McCormick, “Human Gene Therapy: The First Round,” BioTechnol., 3:689 [1985].
Bernstein et al. “Gene Transfer with Retrovirus Vectors,” Genet. Eng., 7:235 [1985].
Felgner and Ringold, “Cationic liposome-mediated transfection,” Nature 337:387-388 [1989].
Curiel et al., “High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes,” Hum. Gene Ther., 3:147-154 [1992].
Dean et al., “Sequence requirements for plasmid nuclear import,” Exp Cell Res., 253(2):713-22 (1999).
Vacik et al., “Cell-specific nuclear import of plasmid DNA,” Gene Ther., 6(6):1006-14 (1999).
Glasser et al., “Human SP-C gene sequences that confer lung epithelium-specific expression in transgenic mice,” Am J Physiol Lung CellMol Physiol., 278(5):L933-45 (2000).
Munkonge et al., “Emerging significance of plasmid DNA nuclear import in gene therapy,” Adv Drug Deliv Rev., 55(6):749-60 (2003).
Young et al., “Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature,” Gene Ther., 10(17):1465-70 (2003).
Glasser et al., “Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse ,” J Biol Chem., 265(35):21986-91 (1990).
Glasser et al., “Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice,” Am J Physiol., 261(4 Pt. 1):L349-56 (1991).
Kelly et al., “Transcription of the Lung-specific Surfactant Protein C Gene Is Mediated by Thyroid Transcription Factor 1,” J Biol Chem., 271(12):6881-8 (1996).
Korfhagen et al., “Cis-Acting Sequences from a Human Surfactant Protein Gene Confer Pulmonary-Specific Gene Expression in Transgenic Mice,” PNAS, 87(16):6122-6 (1990).
Bachurski et al., “Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription,” Mol Cell Biol., 23(24):9014-24 (2003).
Bachurski et al., “Nuclear factor I family members regulate the transcription of surfactant protein-C,” Mol Cell Biol., 272(52):32759-66 (1997).
Liu et al., “GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression,” J Biol Chem., 277(6):4519-25 (2002).
Wilson et al., “Nuclear Import of Plasmid DNA in Digitonin-permeabilized Cells Requires Both Cytoplasmic Factors and Specific DNA Sequences ,” J Biol Chem., 274(31):22025-32 (1999).
Adam et al., “In Vitro Nuclear Protein Import Using Permeabilized Mammalian Cells,” Methods Cell Biol., 35:46

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