Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1997-07-11
1999-04-06
Smith, Lynette F.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
530350, 530324, 530325, 530326, 530327, 530328, 4241841, 4241881, 4242041, 4242081, A61K 3804, A61K 3800, C07K 100, C07K 1700
Patent
active
058919945
ABSTRACT:
A composition is provided which contains a non-naturally occurring peptide or polypeptide comprising at least two or more, and preferably all four amino acid sequences -Asp-Pro-Arg-Leu-Glu-Pro- SEQ ID NO: 6; -Asp-Pro-Lys-Leu-Glu-Pro- SEQ ID NO: 7; -Asp-Pro-Ser-Leu-Glu-Pro- SEQ ID NO: 8; and -Asp-Pro-Asn-Leu-Glu-Pro- SEQ ID NO: 9. This composition, including a number of additional optional peptides or polypeptides, and in a variety of forms, demonstrates a biological activity of inducing antibodies that react with most HIV-1 Tat proteins and impairing the multiplication of HIV-1. Also provided are synthetic genes encoding these peptides, recombinant viruses and commensal bacterium carrying these genes, transfected host cells, and polyclonal or other types of antibodies produced by immunizing other mammals with these aforementioned compositions. Methods for making and using such compositions to lower the viral level of HIV-1 are described.
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Brake, et al, "Characterization of murine monoclonal antibodies . . . " J. Virol. 64(2): 962-965, 1990.
Nelson Brett
Smith Lynette F.
Thymon L.L.C.
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