Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-07-31
2007-07-31
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S252300, C435S483000
Reexamination Certificate
active
10752478
ABSTRACT:
The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.
REFERENCES:
patent: 4418149 (1983-11-01), Ptashne et al.
patent: 4833080 (1989-05-01), Brent et al.
patent: 4948874 (1990-08-01), Kronvall et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5283173 (1994-02-01), Fields et al.
patent: 5284746 (1994-02-01), Sledziewski et al.
patent: 5401629 (1995-03-01), Harpold et al.
patent: 5436128 (1995-07-01), Harpold et al.
patent: 5468614 (1995-11-01), Fields et al.
patent: 5573944 (1996-11-01), Kirschner et al.
patent: 5580736 (1996-12-01), Brent et al.
patent: 5691188 (1997-11-01), Pausch et al.
patent: 5739029 (1998-04-01), King et al.
patent: 5789184 (1998-08-01), Fowlkes et al.
patent: 5876951 (1999-03-01), Fowlkes et al.
patent: 6100042 (2000-08-01), Fowlkes et al.
patent: 6255059 (2001-07-01), Klein et al.
patent: 0 568 925 (1993-11-01), None
patent: WO 8810308 (1988-12-01), None
patent: WO 90/05780 (1990-05-01), None
patent: WO 9112273 (1991-08-01), None
patent: WO 92/05244 (1992-04-01), None
patent: WO 92/08740 (1992-05-01), None
patent: WO 93/10230 (1993-05-01), None
patent: WO 94/23025 (1994-10-01), None
patent: WO 9530012 (1995-11-01), None
patent: WO 9711159 (1997-03-01), None
patent: WO 9813513 (1998-04-01), None
Alison, M.R. et al. “Growth factors and growth factor receptors”British Journal of Hospital Medicine 49(11):774-788 (1993).
Altieri, D.C. “Proteases and protease receptors in modulation of leukocyte effector functions”Journal of Leukocyte Biology 58:120-127 (1995).
Belka, C. et al. “The role of tyrosine kinases and their substrates in signal transmission of hematopoietic growth factors: a short review” Leukemia 9:754-761 (1995).
Birnbaumer, L. “Transduction of receptor signal into modulation of effector activity by G proteins: the first 20 years or so . . . ”FASEB Journal 4:3178-3188 (1990).
Boulay, F. et al. “Synthesis and Use of a Novel N-Formyl Peptide Derivative to Isolate a Human N-Formyl Peptide Receptor cDNA”Biochem. Biophys. Res. Commun. 168(3):1103-1109 (1990).
Boulay; F. et al. “Expression Cloning of a Receptor for C5a Anaphylatoxin on Differentiated HL-60 Cells”Biochemistry 30:2993-2999 (1991).
Brugarolas, J. et al. “Radiation-induced cell cycle arrest compromised by p21 deficiency”Nature 377:552-557 (1995).
Chambers, D.A. et al. “Neuroimmune Modulation: Signal Transduction and Catecholamines”Neurochem. Int. 22(2):95-110 (1993).
Chien, Cheng-Ting, et al. “The Two-Hybrid System: A Method To Identify and Clone Genes For Proteins That Interact With A Protein of Interest”, Proc. Natl. Acad. Sci, USA, vol. 88, pp. 9578-9582, (1991).
Cwirla, S. et al. “Peptides on Phage: A Vast Library of Peptides for Identifying Ligands”Proc. Natl. Acad. Sci. USA 87:6378-6382 (1990).
Devlin, J. et al. “Random Peptide Libraries: A Source of Specific Protein Binding Molecules”Science 249:404-406 (1990).
Dubois, P.M. “Role of the transmembrane and cytoplasmic domains of surface IgM in endocytosis and signal transduction”Eur. J. Immunol. 22:851-857 (1992).
Erickson, D. “Intercepted Messages: New biotechnology drugs target intracellular communication”Scientific American(Nov. 1992):122-123.
Fields, Stanley, et al. “A Novel Genetic System To Detect Protein—Protein Interactions”, Nature, vol. 340, pp. 245-246, (1989).
Funaro, A. et al. “Human CD38 is associated to distinct molecules which mediate transmembrane signaling in different lineages”Eur. J. Immunol. 23:2407-2411 (1993).
Gordon, J. “B-cell signallingviathe C-type lectins CD23 and CD72”Immunology 15(9):411-417 (1994).
Gyuris, Jeno et al. “Cdi1, A Human G1 and S Phase Protein Phosphatase That Assocites With CdK2”, Cell, vol. 75, pp. 791-803, (1993).
Hall, M. et al. “Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins”Oncogene 11:1581-1588 (1995).
Hughes, David, et al. “complementation of byr1 in Fission Yeast By Mammalian MAP Kinase Kinase Requires CoExpression of Raf Kinase”, Nature, vol. 364, pp. 349-352, (1993).
Imamoto, A. et al. “Genetics of signal transduction: tales from the mouse”0Curr. Opion. Gen. &Dev. 4:40-46 (1994).
Jakobs, K.H. et al. “Dual regulation of adenylate cyclase. A signal transduction mechanism of membrane receptors”Basic Res. Cardiol. 81:1-9 (1986).
Kang, Y-S et al., “Effects of expression of mammalian G □ and hybrid mammalian-yeast G□ proteins on the yeast pheromone response signal transduction pathway.” Molecular and Cellular Biology, 10(6):2582-250 (1990).
King, K. et al. “Control of Yeast Mating Signal Transduction by a Mammalian β2-Adrenergic Receptor and Gsα Subunit”Science 250:121-123 (1990).
Koff, Andrew, et al. “Human Cyclin E, A New Cyclin That Interacts With Two Members of the CDC2 Gene Family”, Cell, vol. 66, pp. 1217-1228; (1991).
Kosugi, S. et al. “Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty”Human Molecular Genetics 4(2):183-188 (1995).
Lew, D.J. et al. “Isolation of Three Novel Human Cyclins by Rescue of G1 Cyclin (Cln) Function in Yeast”Cell. 66:1197-1206 (1991).
Linder, M.E. and A.G. Gilman “G Proteins”Scientific AmericanJul. 1992:56-65.
Manfredi, J. et al., “Autocrine stimulation of yeast through human G-coupled receptors,”J. Cell. Biochem., 18B:224 (1994).
Marengere, L.E.M. and T. Pawson “Structure and function of SH2 domains”J. Cell Science Suppl. 18:97-104 (1994).
Milburn, M.V. et al. “Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of ProtooncogenicrasProteins”Science 247:939-945 (1990).
Murphy, A.J.M, et al. “Autocrine Stimulation of Yeast Through Human G-Coupled Receptors,”J. Cell Biochem. 18B:224 (1994).
Murphy, P.M. et al. “Functional Expression of the Human Formyl Peptide Receptor inXenopusOocytes Requires a Complementary Human Factor”J. Biol. Chem. 266(19):12560-12567 (1991).
Ngo, J.T. et al. “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox” In:The Protein Folding Problem and Tertiary Structure PredictionMertz et al. (eds.) Birkhauser, Boston, Massachusetts, p. 433, 492-495 (1954).
Noelle, R.J. et al. “CD40 and it ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation”Immunology Today 13(11):431-433 (1992).
Nye, J.S. and R. Kopan “Vertebrate ligands for Notch”Current Biololgy 5(9):966-969 (1995).
Ranade, K. et al. “Mutations associated with familial melanoma impair p16INK4funtion”Nature Genetics 10:114-116 (1995).
Raymond, M. et al. “Functional Complementation of Yeast ste6 by a Mammalian Multidrug Resistance mdr Gene”Science 256:232-234 (1992).
Reed, R.R. “G Protein Diversity and the Regulation of Signaling Pathways”The New Biologist 2(11):957-960 (1990).
Scott, J.K. and G.P. Smith “Searching for Peptide Ligands with an Epitope Library”Science 249:386-390 (1990).
Suzuki, T. et al. “HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4Aand counteracts its inhibitory activity towards CDK4”EMBO J. 15(7):1607-1614 (1996).
Thien-Khai,
Broach James
Fowlkes Dana M.
Klein Christine A.
Manfredi John
Murphy Andrew J. M.
Cadus Technologies, Inc.
Edwards Angell Palmer & & Dodge LLP
Lauro, Esq. Peter C.
Ulm John
LandOfFree
Methods and compositions for identifying receptor effectors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for identifying receptor effectors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for identifying receptor effectors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3773762