Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-01-17
2006-01-17
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C536S023100, C536S023500
Reexamination Certificate
active
06987021
ABSTRACT:
The present invention relates generally to methods and compositions for identifying morphogenic protein analogs. In one embodiment, this invention relates to an osteogenic protein reponsive transcription inhibitory element. This invention also relates to the identified morphogenic protein analogs which can mimic the biological effects of morphogenic proteins, particularly those relating to the BMP family such as osteogenic protein (OP-1), on the regulation of gene expression and tissue inductive capabilities.
REFERENCES:
patent: 4975526 (1990-12-01), Kuberasampath et al.
patent: 5162114 (1992-11-01), Kuberasampath et al.
patent: 5171574 (1992-12-01), Kuberasampath et al.
patent: 5324819 (1994-06-01), Oppermann et al.
patent: 5344654 (1994-09-01), Rueger et al.
patent: 5354557 (1994-10-01), Oppermann et al.
patent: 5459047 (1995-10-01), Wozney et al.
patent: WO91/18558 (1991-12-01), None
patent: WO95/05846 (1995-03-01), None
patent: WO95/16035 (1995-06-01), None
patent: WO97/05241 (1997-02-01), None
patent: WO97/05285 (1997-02-01), None
patent: WO98/26069 (1998-06-01), None
patent: WO 98/54344 (1998-12-01), None
McCarthy et al. (J of Biological Chemistry (1996) 271(12): 6667-6671).
Yeh et al., “Identification of an Osteogenic Protein-1 (Bone Morphogenetic Protein-7)-Responsive Element in the Promoter of the Rat Insulin-Like Growth Factor-Binding Protein-5 Gene”Endocrinology, 141, pp. 3278-3286 (Sep. 2000).
Canalis et al., “Isolation and Characterization of Insulin-Like Growth Factor I (Somatomedin-C) from Cultures of Fetal Rat Calvariae,”Endocrinology, 122, pp. 22-27 (1988).
Canalis et al., “Skeletal Growth Factors Regulate the Synthesis of Insulin-Like Growth Factor Binding Protein-5 in Bone Cell Cultures,”J. Biol. Chem., 270, pp. 10771-10776 (1995).
Dong et al., “Insulin-Like Growth Factor (IGF) I and Retinoic Acid Induce the Synthesis of IGF-Binding Protein 5 in Rat Osteoblastic Cells,”Endocrinology, 136, pp. 2000-2006 (1995).
Gabbitas et al., “Cortisol Inhibits the Synthesis of Insulin-Like Growth Factor-Binding Protein-5 in Bone Cell Cultures by Transcriptional Mechanisms,”J. Biol. Chem., 271, pp. 9033-9038 (1996).
Hock et al., “Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication,”Endocrinology, 122, pp. 254-260 (1988).
Ji, et al., “Activation of the Insulin-Like Growth Factor-Binding Protein-5 Promoter in Osteoblasts by Cooperative E Box, CCAAT Enhancer-Binding Protein, and Nuclear Factor-1 Deoxyribonucleic Acid-Binding Sequences,”Endocrinology, 140, pp. 4564-4572 (1999).
Liem et al., “Dorsal Differentiation of Neural Plate Cells Induced by BMP-Mediated Signals from Epidermal Ectoderm,”Cell, 82, pp. 969-979 (1995).
McCarthy et al., “Regulatory Effects of Insulin-Like Growth Factors I and II on Bone Collagen Synthesis in Rat Calvarial Cultures,”Endocrinology, 124, pp. 301-309 (1989).
Pash et al., “Transcriptional Regulation of Insulin-Like Growth Factor-Binding Protein-5 by Prostaglandin E2in Osteoblast Cells,”Endocrinology, 137, pp. 2375-2382 (1996).
Reddi, “Cell Biology and Chemistry of Endochondral Bone Development,”Collagen Rel. Res., 1, pp. 209-226 (1981).
Sampath and Reddi, “Dissociative Extraction and Reconstitution of Extracellular Matrix Components Involved in Local Bone Differentiation,”Proc. Natl. Acad. Sci. USA, 78, pp. 7599-7603 (1981).
Sampath and Reddi, “Homology of Bone-Inductive Proteins From Human, Monkey, Bovine, and Rat Extracellular Matrix,”Proc. Natl. Acad. Sci. USA, 80, pp. 6591-6595 (1983).
Yeh et al., “Osteogenic Protein-1-Mediated Insulin-Like Growth Factor Gene Expression in Primary Cultures of Rat Osteoblastic Cells,”Endocrinology, 137, pp. 1921-1931 (1996).
Yeh et al., “Osteogenic Protein-1and Insulin-Like Growth Factor I Synergistically Stimulate Rat Osteoblastic Cell Differentiation and Proliferation,”Endocrinology, 138, pp. 4181-4190 (1997).
Yeh et al., “Osteogenic Protein-1 Regulates Insulin-Like Growth Factor-I (IGF-I), IGF-II, and IGF-Binding Protein-5 (IGFBP-5) Gene Expression in Fetal Rat Calvaria Cells by Different Mechanisms,”J. Cell Physiol., 175, pp. 78-88 (1998).
Lee John C.
Yeh Lee-Chuan C.
Fish & Neave IP Group of Ropes & Gray LLP
Haley Jr. James F.
Horlick Kenneth R.
Mangasarian Karen
Stryker Corporation
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