Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-05-02
2006-05-02
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S320100
Reexamination Certificate
active
07037656
ABSTRACT:
A yeast-based system and methods of use therefore are provided for identifying new molecules which activate nuclear receptors in a ligand-dependent fashion. In a preferred embodiment, a method is provided utilizing ecdysone receptor, USP and GRIP I encoding expression vectors which may be used to advantage for screening new and useful insecticidal compounds, detecting insecticidal residues as well as to regulate expression of a gene of interest in a host in a ligand-dependent manner.
REFERENCES:
patent: WO 97/45737 (1997-12-01), None
Tran, Hiep T., et al., “Reconstruction of Ligand-Dependent Transactivation ofChoristoneura fumiferanaEcdysone Receptor in Yeast”, Molecular Endocrinology 15(7): 1140-1153 (2001).
Tran, Hiep T., et al., “Requirement of co-factors for the ligand-mediated activity of the insect ecdysteriod receptor in yeast”, Journal of Molecular Endocrinology, 27: 191-209 (2001).
Dela Cruz, Fernando, et al., “Drosophila Ecdysone Receptor Functions as a Constitutive Activator in Yeast”, J. Steroid Biochem. Molec. Biol. 62(4):353-359 (1997).
Walfish, Paul G., et al., “Yeast hormone response element assays detect and characterize GRIP1 coactivator-dependent activation of transcription by thyroid and retinoid nuclear receptors”, Proc. Natl. Acad. Sci. USA 94: 3697-3702 (1997).
Askari Hossein
Butt Tauseef
Schwartz Michael
Shaaban Salam
Tran Hiep Tuan
Dann Dorfman Herrell and Skillman
Ketter James
Lifesensors, Inc.
Rigaut Kathleen D.
LandOfFree
Methods and compositions for identifying ligands for nuclear... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for identifying ligands for nuclear..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for identifying ligands for nuclear... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3605811