Methods and compositions for identifying inhibitors of papilloma

Details Methods and compositions for identifying inhibitors of papilloma Methods and compositions for identifying inhibitors of papilloma

1994-09-23

1997-04-15

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352351, 435239, 424 941, 424 942, 536 2372, 530300, C12Q 168, C12N 700, A61K 3843, C07K 200

Patent

active

056208499

ABSTRACT:
Compositions and methods for identifying inhibitors of papilloma virus replication are described consisting of soluble cellular extracts supplemented with purified viral E1 and E2 proteins.

REFERENCES:
Ira L. Blitz et al., "The 68-Kilodalton E1 Protein of Bovine Papillomavirus Is a DNA Binding Phosphoprotein Which Associates with the E2 Transcriptional Activator in Vitro", J. of Virol. (1991) 65(2):649-656.
Cheng-Ming Chiang et al., "An E1M E2C Fusion Protein Encoded by Human Papillomavirus Type 11 is a Sequence-Specific Transcription Repressor", J. of Virol. (1991) 65(6):3317-3329.
Jonathan D. Knight et al., "The activation domain of the bovine papillomavirous E2 protein mediates association of DNA-bound dimers to form DNA loops", Proc. Natl. Sci. USA (1991) 88:3204-3208.
Rong Li et al., "Direct Interaction between Sp1 and the BPV Enhancer E2 Protein Mediates Synergistic Activation of Transcription" Cell (1991) 65:493-505.
Joachim J. Li et al., "Simian virus 40 DNA replication in vitro" Proc. Natl. Acad. Sci. USA (1984) 81:6973-6977.
Ian J. Mohr et al., "Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator" Science (1990) 250:1694-1699.
Hiromasa Sekine et al., "Expression of human papillomavirus type 6b E2 gene product with DNA-binding activity in insect (Bombyx mori) cells using a baculovirus expression vector" Gene (1988) 65:187-193.
Liu Yang et al., "Activation of BPV-1 replication in vitro by the transcription factor E2" Nature (1991) 353:628-632.
Gangemi et al. 1994 Antiviral Res. 24:175-190.
Chalberg 1989 Annu rev. Biochem 58:671-717.
Gilbert et al. 1987, Cell. 50:59-68.
Ustav & Stenland. 1991 EMBO J. 10(2):449.
Li & Kelly 1984. PNAS. 81:6973.

Affiliated with

Also associated with

Rating

Methods and compositions for identifying inhibitors of papilloma does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for identifying inhibitors of papilloma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for identifying inhibitors of papilloma will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-359985