Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-12-17
2010-11-30
Robinson, Hope A (Department: 1652)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C424S422000, C424S423000, C424S093700, C424S093210
Reexamination Certificate
active
07842669
ABSTRACT:
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration and/or functional repair of articular cartilage tissue.
REFERENCES:
patent: 4642120 (1987-02-01), Nevo et al.
patent: 5658882 (1997-08-01), Celeste et al.
patent: 5700774 (1997-12-01), Hattersley et al.
patent: 5713374 (1998-02-01), Pachence et al.
patent: 5786217 (1998-07-01), Tubo et al.
patent: 5842477 (1998-12-01), Naughton et al.
patent: 6001352 (1999-12-01), Boyan et al.
patent: 6727224 (2004-04-01), Zhang et al.
patent: 7323445 (2008-01-01), Zhang et al.
patent: 1 006 957 (2003-11-01), None
patent: WO 94/01557 (1994-01-01), None
patent: WO 95/33502 (1995-12-01), None
patent: WO 96/14335 (1996-05-01), None
patent: WO 96/33215 (1996-10-01), None
patent: WO 96/39170 (1996-12-01), None
patent: WO 96/40297 (1996-12-01), None
patent: WO 98/00183 (1998-01-01), None
patent: WO 98/31788 (1998-07-01), None
Brown et al., “Osteochondral Allografts With an Intramedullary Muscle Flap in Rabbits,” Clin. Ortho. Related Res. 334:282-290 (1997).
Bugbee et al., “Osteochondral Allograft Transplantation,” Clin. Sports Med. 18:67-75 (1999).
Cook et al., “Osteogenic Protein-1”, Clin. Ortho. Related Res. 324:29-38 (1996).
European Search Report, EP Application 03 02 8308, dated Jan. 23, 2004.
Gao et al., “Tissue-Engineered Fabrication of an Osteochondral Composite Graft Using Rat Bone Marrow-Derived Mesenchymal Stem Cells,” Tissue Eng. 4:363-371 (2001).
Gilbert, Am. “Current Treatement Options for the Restoration of Articular Cartilage,” J. Knee Surg. 11:42-46 (1998).
Grgic et al., “Regeneration of Articular Cartilage Defects in Rabbits by Osteogenic Protein-1 (Bone Morphogenetic Protein-7),” Acta Med. Croatica 51:23-27 (1997).
Hangody et al., “MosaicPlasty Osteochondral Grafting,” Guide to MosaicPlasty Osteochondral Grafting, Smith & Nephew (2001).
Hangody et al., “Mosaicplasty for the Treatment of Articular Cartilage Defects: Application in Clinical Practice,” Orthopedics 21:751-756 (1998).
Hollnagel et al., “Parathyroid Hormone (PTH) and PTH/PTHrP-Receptor Mediated Stimulation of Osteochondrogenic Development in BMP-Transfected C3H10T½ Mesenchymal Progenitor Cells Takes Place during the Early Commitment Period,” Calcified Tissue Intl., 56:430 (1995) (abstract).
Klein-Nulend et al., “Stimulation of Cartilage Differentiation by Osteogenic Protein-1 in Cultures of Human Perchondrium,” Tissue Engineering, 4:305-313 (1998).
Luyten et al., “Recombinant Bone Morphogenetic Protein-4, Transforming Growth Factor-β1, and Activin A Enhance the Cartilage Phenotype of Articular Chondrocytes in Vitro,” Exp. Cell. Res., 210(2):224-229 (1994).
Mow et al., “Experimental Studies on Repair of Large Osteochondral Defects at a High Weight Bearing Area of the Knee Joint: A Tissue Engineering Study,” J. Biomech. Eng. 113:198-207 (1991).
Preliminary Amendment, filed Apr. 2, 2008, Pending U.S. Appl. No. 11/928,925.
Preliminary Amendment, filed Apr. 2, 2008, Pending U.S. Appl. No. 11/928,977.
Preliminary Amendment, filed Apr. 2, 2008, Pending U.S. Appl. No. 11/929,031.
Reddi et al., “Bone Morphogenetic Proteins: Potential Role in Osteoporosis,” Osteoporosis, Academic Press, pp. 281-287 (1996).
Sato et al., “Bone Morphogenetic Protein-induced Cartilage Development in Tissue Culture,” Clin. Orthopaedics Related Res., 183:180-187 (1984).
Sellers et al., “The Effect of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) on the Healing of Full-Thickness Defects of Articular Cartilage,” J. Bone Joint Surg. 79-A(10):1452-1463 (1997).
Takagi et al., “The Role of Bone Marrow in Bone Morphogenetic Protein-induced Repair of Femoral Massive Diaphyseal Defects,” Clin. Orthopaed. Related Res., 171:224-231 (1982).
Tomford et al., “Fresh and Frozen Articular Cartilage Allografts,” Orthopaedics 15:1183-1188 (1992).
Van Beuningen et al., “Differential effects of local application of BMP-2 of TGF-β1 on both articular cartilage composition and osteophyte formation,” Osteoarthritis & Cartilage 6:306-317 (1998).
Vunjak-Novakovic et al., “Bioreactor cultivation of osteochondral grafts,” Orthod. Craniofacial Res. 8:209-218 (2005).
Wang, E.E., “Bone morphogenetic proteins (BMPs): therapeutic potential in healing bony defects,” Trends in Biotech., 11:379-383 (1993).
Wuisman et al., “The Use of Massive Allografts for Reconstruction after Resection of Bone Tumors of the Limb,” Z. Orthop. 133:166-175 (1995) (Abstract only).
Tsukahara et al., “Mosaicplasty for spontaneous osteonecrosis of the medial femoral condyle,” Kansetsukyou 24:165-8 (1999).
Morris Elisabeth
Peluso Diane
Zhang Renwen
Genetics Institute LLC
Robinson Hope A
Wyeth LLC
LandOfFree
Methods and compositions for healing and repair of articular... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for healing and repair of articular..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for healing and repair of articular... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4173485