Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-02-24
1997-07-29
Stone, Jacqueline M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424 9321, 4351723, 4353201, 435325, 435354, 435366, 435369, 435370, A61K 4800, C12N 1500
Patent
active
056522240
ABSTRACT:
The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic cell; and a human VLDL receptor gene operatively linked to regulatory sequences directing its expression. The vector is capable of expressing the normal VLDL receptor gene product in hepatic cells in vivo or in vitro. This viral vector is useful in the treatment of metabolic disorders caused by the accumulation of LDL in plasma, such as familial hypercholesterolemia or familial combined hyperlipidemia.
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Kozarsky Karen
Strauss, III Jerome
Wilson James M.
Milne Andrew
Stone Jacqueline M.
The Trustees of the University of Pennsylvania
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