Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-07-12
2011-07-12
Pak, Yong D (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S227000, C435S455000, C435S325000, C435S252300, C435S320100, C435S004000, C435S440000, C424S093100, C514S04400A, C536S023200
Reexamination Certificate
active
07977049
ABSTRACT:
The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.
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Dulyaninova et al. Salvage pathway for NAD biosynthesis in Brevibacterium ammoniagenes: regulatory properties of triphosphate-dependent nicotinate phosphoribosyltransferase. Biochim
Bitterman Kevin J.
Sinclair David A.
Pak Yong D
President and Fellows of Harvard College
Wolf Greenfield & Sacks P.C.
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