Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1998-08-18
2000-09-26
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424490, 424430, 424434, 424435, 424436, A61K 952, A61K 4702
Patent
active
061239658
ABSTRACT:
Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery devices. The bioadhesive properties of a polymer are enhanced by incorporating a metal compound into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Metal compounds which enhance the bioadhesive properties of a polymer include water-insoluble metal compounds such as water-insoluble metal oxides, including oxides of calcium, iron, copper and zinc. The metal compounds can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, metal oxides can be incorporated within polymers used to form or coat drug delivery devices, such as microspheres, which contain a drug or diagnostic agent. The metal oxides can be provided in the form of a fine dispersion of particles on the surface of a polymer that coats or forms the devices, which enhances the ability of the devices to bind to mucosal membranes. The polymers, for example in the form of microspheres, have improved ability to adhere to mucosal membranes, and thus can be used to deliver a drug or diagnostic agent via any of a range of mucosal membrane surfaces including those of the gastrointestinal, respiratory, excretory and reproductive tracts.
REFERENCES:
patent: 2675619 (1954-04-01), Cone
patent: 2677700 (1954-05-01), Jackson et al.
patent: 2979578 (1961-04-01), Curtis et al.
patent: 3036118 (1962-05-01), Jackson et al.
patent: 3535307 (1970-10-01), Moss et al.
patent: 3563978 (1971-02-01), Ochs
patent: 3829506 (1974-08-01), Schmolka et al.
patent: 4169804 (1979-10-01), Yapel, Jr.
patent: 4861627 (1989-08-01), Mathiowitz
patent: 4938763 (1990-07-01), Dunn et al.
patent: 4976968 (1990-12-01), Steiner
patent: 5019400 (1991-05-01), Gombotz et al.
patent: 5122418 (1992-06-01), Nakane et al.
patent: 5213788 (1993-05-01), Ranney
patent: 5219554 (1993-06-01), Groman et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5281408 (1994-01-01), Unger
patent: 5427767 (1995-06-01), Kresse et al.
patent: 5498421 (1996-03-01), Grinstaff et al.
patent: 5527521 (1996-06-01), Unger
patent: 5547656 (1996-08-01), Unger et al.
patent: 5547682 (1996-08-01), Chagnon et al.
patent: 5549915 (1996-08-01), Volkonsky et al.
patent: 5565215 (1996-10-01), Gref et al.
patent: 5641515 (1997-06-01), Ramtoola
patent: 5651989 (1997-07-01), Volkonsky et al.
Allen, et al. Mucus Glycoprotein Structure Gel Formation and Gastrointestinal Mucus Function: in J. Nugent & M O'Conner, Eds., Mucus and Mucosa, Ciba Foundation Symposium 109, Pitman, London, 137:137-156 (1984).
Beck, et al. "A New Long Acting Injectable Microcapsule System for the Administration of Progesterone" Fertil. Steril. 31:545-551 (1979).
Benita, et al. "Characterization of Drug-Load Poly (d-l-lactide) Microsphere," J. Pharm Sci, 73: 1721-1724 (1984).
Duchene, et al. "Pharmaceutical and Medical Aspects of Bioadhesive Systems for Drug Administration" Drug Dev. Ind. Pharm 14:283-318 (1988).
Edelman, et al. "Perivascular and Intravenous Administration of Basic Fibroblast Growth Factor: Vascular and Solid Organ Deposition," Proc. Natl. Acad. Sci., USA 30:1513-1517 (1993).
Furia, Ed., CRC Handbook of Food Additives, Cleveland, OH 1968.
Gurney, et al. "Bioadhesive Intraoral Release Systems: Design, testing and Analysis," Biomaterials, 5:336-340 (1984).
Harada, et al. "Basic Fibroblast Growth Factor Improves Myocardial Function in Chronically Ischemic Porcine Hearts," J. Clin. Invest. 94:623-630 (1994).
Horowitz, et al. "Use of Enzymes in Elucidation of Structure," The Glycoconjugates, pp. 560 (New York: Academic Press, Inc. 1977).
Horowitz, "Mucopolysaccharides and Glycoproteins of the Alimentary Tract" in Alimentary Canal (eds. c. F Code), pp. 1063-1085 (Washington: American Physiological Society, 1967).
Labat-Robert, et al. "Glycoproteins du Mucus gastrique: Structure Fonctions Et Pathologie et Biologie," Path. Biol., 24:241 (1979).
Labhasetwar. et al. "Sotalol Controlled- Release Systems for Arrthmias: In Vitro Characterization, in Vivi Drug Disposition and Electrophysiologic Effects," J. Controlled Rel. Sci, 83(2):156-164 (1994).
Lehr, et al. "Intestinal Transit of Bioadhesive Microspheres in an in Situ Loop in the Rat- A Comparative Study with Copolymers and Blends based on Poly(Acrylic Acid)," J. Controlled Rel. Soc. 13: 51-62 (1990).
Lee, K., et al., "Design of Oral Patches for the Treatment of Aphthous Stomatitis: Drug Layer", Yakche Hakhoechi 25(4):339-45 (S. Korea 1995); Chemical Abstracts 124(22), Abstract No. 298738 (May 27, 1996).
Mathiowitz, et al. "Morphology of Polyanhydride Microsphere Delivery Systems," J. Scanning Microscopy 4: 329-340 (1990).
Mathiowitz, et al. "Novel Microcapsules for Delivery Systems," Reactive Polymers, 6: 275-283 (1987).
Mikos, et al. "Intraction of Polymer Microspheres with Mucin Gels as a Means of Characterizing Polymer Retention on Mucus," J. Colloid Interface Sci. 143: 366-373 (1991).
Park, et al. "Alternative Approaches to Oral Controlled Drug Delivery: Bioadhesives and in-Situ Systems" in J.M. Anderson and S.W.>Kim, Eds., Recent Advances in Drug Delivery pp. 163-183 (Plenum Press, New York, 1984).
Pigman, et al. "Submaxillary Gland Glycoproteins" in Glycoproteins: Their Composition, Structure and Function (eds. A. Gottschalk), pp. 434-445 (Amsterdam: Elsevier Pub. Co., Inc., 1966).
Scawen, et al. "The Action of Proteolytic Enzymes on the Glycoprotein form Pig Gastric Mucus," Biochem. J. 163:363-368 (1997).
Smart, et al. "An In-vitro Investigation of Mucosa-adhesive Materials for Use in Controlled Drug Delivery" J. Pharm. Pharmacol 36:295-299 (1984).
Spiro, "Glycoproteins," Annual Review of Biochemistry, 39: 599-638 (1970).
Tutwiler, et al. "A Pharmacologic profile of McN-3495 [N-(1 -methyl-2-pyrrolidinylidene.sub.-- -N'-phenyl-1-pyrrolidenecarboximidamide], A New, Orally Effective Hypoglycemic Agent" Diabetes 27: 856-867 (1978).
Jacob Jules S.
Mathiowitz Edith
Brown University Research Foundation
Kulkosky Peter F.
LandOfFree
Methods and compositions for enhancing the bioadhesive propertie does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for enhancing the bioadhesive propertie, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for enhancing the bioadhesive propertie will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2097698