Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1985-01-09
1989-05-02
Warden, Robert J.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
128653, 128654, 436173, 436806, 514492, 514501, 514502, 514505, 534 15, 534 16, 556 45, 556 57, 556138, 562564, 562565, A61K 4900, A61B 505, A61B 600
Patent
active
048266736
ABSTRACT:
The disclosure is directed to compounds of the formula: ##STR1## wherein n=0, 1, 2, 3 or 4, and R.sub.1 and R.sub.2 may be the sam e or different and are selected from the group consisting of hydrogen and lower alkyl and hydroxy lower alkyl groups containing between 1 and 6 carbon atoms. Complexes of iron(II), iron(III), manganese(II), manganese(III), gadolinium(III), chromium(III), cobalt(II), and nickel(II) and such compounds are useful for enhancing magnetic resonance images of body organs and tissues. Illustrative complexes include (N,N"-bis[N-(2,3-dihydroxypropyl) carbamoylmethyl]diethylenetriamine-N,N',N"-triaceto)-iron(III), (N,N"-bis[N-(2,3-dihydroxypropyl)carbamoylmethyl]diethylenetriamine-N,N',N "-triaceto)manganese(II), (N,N"-bis[N-(2,3-dihydroxypropyl) )carbamoylmethyl]diethylenetriamine-N,N',N"-triaceto)gadolinium(III) and (N,N'-bis[N-(2,3-dihydroxypropyl)-carbamoylmethyl]ethylenediamine-N,N'-dia ceto)manganese(II).
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patent: 4647447 (1987-03-01), Gries
patent: 4687659 (1987-08-01), Quay
Weinmann et al., AJR, vol. 142, (1984), pp. 619-624.
Dean Richard T.
Lin Youlin
Weber Robert W.
White David H.
Mallinckrodt Inc.
Warden Robert J.
Wieder Stephen C.
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