Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-09-02
2009-10-06
Hartley, Michael G (Department: 1618)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S453000, C424S401000
Reexamination Certificate
active
07598291
ABSTRACT:
A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
REFERENCES:
patent: 4820724 (1989-04-01), Nimni
patent: 5198465 (1993-03-01), Dioguardi
patent: 5487776 (1996-01-01), Nimni
patent: 5709868 (1998-01-01), Perricone
patent: 5804168 (1998-09-01), Murad
patent: 5935994 (1999-08-01), Nimni
patent: 6426080 (2002-07-01), Golz-Berner et al.
patent: 6565912 (2003-05-01), Gugger et al.
patent: 6576271 (2003-06-01), Nair et al.
Entrez Protein Entry for human collagen, locus BAA04809, accessed Aug. 30, 2007.
Podda, M. & Grundmann-Kollmann, M., “Low Molecular Weight Antioxidants and Their Role in Skin Aging,” Clin. Exp. Dermatol. 26: 578-582 (2001).
Biewenga, G.P., et al., “The Pharmacology of the Antioxidant Lipoic Acid,” Gen. Pharmacol. 29: 315-331 (1997).
Packer, L., “Antioxidant Properties of Lipoic Acid and Its Therapeutic Effects in Prevention of Diabetes Complications and Cataracts,” Ann. N.Y. Acad. Sci. 738: 257-264 (1994).
Teichert, J. et al., “Investigations on the Pharmacokinetics of Alpha-Lipoic Acid in Healthy Volunteers,” Int. J. Clin. Pharmacol. Ther.: 36: 625-268 (1998).
Hagen, T.M., et al., “(R)-Alpha-Lipoic Acid-Supplemented Old Rats Have Improed Mitochndrial Function, Decreased Oxidative Damage, and Increased..” FASEB J. 13: 411-418 (1999).
Lykkesfeldt, J. et al., “Age-Associated Decline in Ascorbic Acid Concentration, Recycling, and Biosynthesis in Rat Hepatocytes—Reversal with (R)-Alpha-Lipoic Acid Supp,” FASE B Journal 12, 1183-1189 (1998).
Khanna, S. et al., “Cytokine-Induced Glucose Uptake in Skeletal Muscle: Redox Regulation and the Role of Alpha-Lipoic Acid,” Am. J. Physiol. 276:R1327-R21333 (1999).
Podda, M. et al., “Kinetic Study of Cutaneous and Subcutaneous Distribution Following Topical Application of . . . ,” Biochem. Pharmacol. 52: 627-633 (1996).
Cordoba, F. & Ninni, M., “Chondroitin Sulfate and Other Sulfate Containing Chondroprotective Agents May Exhibit Their Effect . . . ” Osteoarthritis & Cartilage 11: 228-230 (2003).
Han, B., et al., “Proanthocyanidin: A Natural Crosslinking Reagent for Stailizing Collagen Matrices,” J. Biomed. Mater. Res. 65A:118-24 (2003.
Han Bo
Nimni Marcel
Farber Michael B.
Hartley Michael G
Westerberg Nissa M
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