Methods and compositions for enhanced protein expression...

Details Methods and compositions for enhanced protein expression... Methods and compositions for enhanced protein expression...

2005-11-15

2005-11-15

Oen, William (Department: 2855)

Measuring and testing

Fluid pressure gauge

Bourdon

Reexamination Certificate

active

06964199

ABSTRACT:
The present invention in the field of biotechnology, provides methods and compositions for providing enhanced growth of, and/or protein production from, cultured mammalian host cells used for the production of commercially useful amounts of expressed proteins, by the use of at least one Bcl2 encoding nucleic acid provided or transcribed in the host cell.

REFERENCES:
patent: 9183983 (1997-05-01), None
E. Suzuki, “Establishing apoptosis resistant cell lines for improving protein productivity of cell culture”, Cypotechnology, vol. 23, 1997, pp. 55-59, XP 001009825.
Database WPI week 9735, Derwent Publications Ltd., London, GB, An 1997-380167 XP002208597.
N. Kim et al., “Overexpression of blcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production.”, Biotechnology and Bioengineering, vol. 71, No. 3, 2000, pp. 184-193, XP002208594, New York NY.
B. Tey et al.: “Influence of bcl-2 on cell death during the cultivation of a Chinese hamster ovary cell line expressing a chimeric antibody.” Biotechnology and Bioengineering, vol. 6, No. 1, Apr. 5, 2000, pp. 31-43, XP002208595, New York, NY.
N. Simpson et al, “Prevention of hybridoma cell death by bcl-2 during suboptimal culture conditions.” Biotechnology and Bioengineering, vol. 54; No. 1, 1997, pp. 1-16, XP002208596.
D. Fassnacht et al:, “Influence of bcl-w on antibody productivity in high cell density perfusion cultures of hybridoma.” Cytotechnolgoy, vol. 30, No. 1-3, 1999, pp. 95-105, XP001009822.
International Search Report for application No. PCT/US01/45563 dated Aug. 18, 2002.

Affiliated with

Also associated with

Rating

Methods and compositions for enhanced protein expression... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for enhanced protein expression..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for enhanced protein expression... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3474360