Methods and compositions for efficient nucleic acid sequencing

Details Methods and compositions for efficient nucleic acid sequencing Methods and compositions for efficient nucleic acid sequencing

2006-07-04

2006-07-04

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200, C435S007100, C435S287100, C536S023100, C536S024300, C536S024320, C536S024330

Reexamination Certificate

active

07070927

ABSTRACT:
Disclosed are novel methods and compositions for rapid and highly efficient nucleic acid sequencing based upon hybridization with two sets of small oligonucleotide probes of known sequences. Extremely large nucleic acid molecules, including chromosomes and non-amplified RNA, may be sequenced without prior cloning or subcloning steps. The methods of the invention also solve various current problems associated with sequencing technology such as, for example, high noise to signal ratios and difficult discrimination, attaching many nucleic acid fragments to a surface, preparing many, longer or more complex probes and labelling more species.

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