Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-04-05
2005-04-05
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S320100, C435S455000, C435S456000, C435S325000, C435S069100, C536S023100, C536S023500, C536S023200, C536S023700, C536S024100
Reexamination Certificate
active
06875610
ABSTRACT:
The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a recipient cell. The two vectors complement each other and thus allow viral replication, in a synergistic combination which enhances both gene delivery and gene expression of genetic sequences contained within the vector.
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Higginbotham James N.
Link Charles J.
Ramsey William J.
Guzo David
Human Gene Therapy Research Institute
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