Methods and compositions for diseases associated with...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C424S450000, C424S193100, C424S194100, C424S420000, C530S326000, C530S323000, C530S300000, C514S002600

Reexamination Certificate

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07067133

ABSTRACT:
The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.

REFERENCES:
patent: 6743427 (2004-06-01), Schenk
patent: 6787637 (2004-09-01), Schenk
patent: WO 99/27944 (1999-06-01), None
Walter et al., 1997, Biochem and Biophys Research Comm, 233, pp. 760-764.
Glenner, M.D., George G., et al., “Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein”, Biochemical and Biophysical Research Communications, vol. 120, No. 3, pp. 885-890 (1984).
Potter, Huntington, et al., “The Potential of BACE Inhibitors for Alzheimer's Therapy”, Nature Biotechnology, vol. 18, pp. 125-126 (2000).
Schenk, Dale, et al., “Immunization with Amyloid-β Attenuate Alzheimer-Disease-Like Pathology in the PDAPP Mouse”, Nature, vol. 400, pp. 173-177 (1999).
Solomon, Beka, et al., “Disaggregation of Alzheimer β-Amyloid by Site-Directed MAb”, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 4109-4112 (1997).
Tamaoka, Akira, et al., “Identification of a Stable Fragement of the Alzheimer Amyloid Precursor Containing the β-protein in Brain Microvessels”, Proc. Natl. Acad. Sci. USA, vol. 89, pp. 1345-1349 (1992).
Tosi, Pierre-François, et al., “Immune Response Against the Murine MDRI Protein Induced by Vaccination With Synthetic Lipopeptides in Liposomes”, Biochemical and Biophysical Research Communications, vol. 212, No. 2, pp. 494-500 (1995).

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