Methods and compositions for diagnosis and treatment of patholog

Details Methods and compositions for diagnosis and treatment of patholog Methods and compositions for diagnosis and treatment of patholog

1997-03-14

2000-02-15

Brusca, John S.

Chemistry: molecular biology and microbiology

Vector, per se

536 235, 536 237, 536 2372, 536 241, 536 245, 5303871, 4284022, C12N 1563, C12N 1512, C12N 1533, C07H 2100

Patent

active

06025193&

ABSTRACT:
Methods and compositions are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The methods comprise administering to a patient having such a pathological condition a plasmid encoding an oligonucleotide, antisense to one or more RNA molecules encoding one of the several dopamine receptors, thereby selectively controlling expression of one or more dopamine receptor subtypes, and alleviating the pathological conditions related to their expression. The vectors are targeted to specific regions of the brain via complexation with antibody studded liposomes.

REFERENCES:
Milner et al. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nature Biotechnology vol. 15 pp. 537-541, 1997.
Geisert et al. Transfecting neurons and glia in the rat using pH-sensitive immunoliposomes. Neuroscience Letters vol. 184 pp. 40-43, 1995.
Neckers et al. Antisense technology: biological utility and practical considerations. Am. J. Physiol. vol. 265 pp.L1-L12, 1993.
Orkin et al. Report and recommendations of the panel to assess the NIH investment in research on gene therapy. Pp. 1-41, 1995.

Affiliated with

Also associated with

Rating

Methods and compositions for diagnosis and treatment of patholog does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for diagnosis and treatment of patholog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for diagnosis and treatment of patholog will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1905065