Methods and compositions for diagnosis and treatment of asthma

Details Methods and compositions for diagnosis and treatment of asthma Methods and compositions for diagnosis and treatment of asthma

2011-04-05

2011-04-05

Pak, Michael (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000

Reexamination Certificate

active

07919584

ABSTRACT:
This invention relates to methods of reducing inflammatory effects in mammalian cells by treatment with compounds that interfere with calcium activated chloride channel function. The invention discloses methods of treating these disorders by administering inhibitors that disrupt protein-protein interactions involved in these disorders, screening methods to identify such inhibitors and specific compositions useful for treating these disorders.

REFERENCES:
Nakanishi et al. (2001) PNAS 98: 5175-5180.
Gruber et al. American J. Physiol 276: (cell physiol. 45:C1261-C1270).

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