Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1991-06-28
1994-06-28
Parr, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, C12Q 168, C12P 1934
Patent
active
053246306
ABSTRACT:
A chromosomal gene of Borrelia burgdorferi which encodes a conserved antigen of approximately 79 kD has been isolated and sequenced. The chromosomal gene, the gene product, and antibodies to the gene product may be used in diagnostic methods for the detection of Borrelia burgdorferi infection. The antigen and fragments thereof are suitable for use in vaccine compositions and methods.
REFERENCES:
LeFebvre, R. B., et al. The 83-k70 dalton antigen of Borrelia burgdorferi which stimulates . . . J. Clin. Microbiol. (Jul., 1990) 28:1673-1675.
Perng, G.-G., et al. Further characterization of a potent immunogen and the chromosomal . . . Infect. Immun. (Jun., 1991) 59:2070-2074.
Craft et al. (1986) Clin. Invest. 78:934-938 "Antigens of Borrelia burgdorferi Recognized during Lyme Disease".
Grodzicki et al. (1988) J. Infect. Dis. 157:790-797 "Comparison of Immunoblotting and Indirect Enzyme-Linked Immunoadsorbent Assay Using Different Antigen Preparations for Diagnosing Early Lyme Disease".
Nadal et al. (1989) Pediatri. Res. 26:377-382 "Immunoblot Analysis of Antibody Binding to Polypeptides of Borrelia burgdorferi in Children with Different Clinical Manifestations of Lyme Disease".
LeFebvre et al. (1990) J. Clin. Microbiol. 28:1673-1675 "The 83-Kilodalton Antigen of Borrelia burgdorferi Which Immunoadsorbent Assay Using Different Antigen Preparations for Diagnosing Early Lyme Disease".
Perng et al. (1991) Infect. Immun. 59:2070-2074 "Further Characterization of a Potent Immunogen and the Chromosomal Gene Encoding It in the Lyme Disease Agent, Borrelia burgdorferi".
Harlow et al. "Antibodies A Laboratory Manual", 1988 by Cold Spring Harbor Laboratory (New York), see pp. 141, 142, 516.
Lefebvre Rance B.
Perng Guey-Chuen
Parr Margaret
Schreiber David
The Regents of the University of California
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