Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-01-17
1999-11-02
Housel, James C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 237, 536 241, 435 72, 435 693, 4351721, 4353201, 4241841, C07H 2104
Patent
active
059773391
ABSTRACT:
A chromosomal gene of Borrelia burgdorferi which encodes a conserved antigen of approximately 79 kD has been isolated and sequenced. The chromosomal gene, the gene product, and antibodies to the gene product may be used in diagnostic methods for the detection of Borrelia burgdorferi infection. The antigen and fragments thereof are suitable for use in vaccine compositions and methods.
REFERENCES:
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Lefebvre et al. J. Clin. Microbiol. 1990. 28(7): 1673-1675.
Cover of J. Clin. Micro. (Jul. 1990 issue), Jun. 26, 1990.
Craft et al. (1986) Clin. Invest. 78:934-938 "Antigens of Borrelia burgdorferi Recognized during Lyme Disease".
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Nadal et al. (1989) Pediatri. Res. 26:377-382 "Immunoblot Analysis Of Antibody Binding to Polypeptides of Borrelia burgdorferi in Childeren with Different Clinical Manifestations of Lyme Disease".
LeFebvre et al. (1990) J. Clin. Microbiol. 28:1673-1675 "The 83-Kilodalton Antigen of Borrelia burgdorferi Which Immunoadsorbent Assay Using Different Antigen Preparations for Diagnosing Early Lyme Disease".
Perng et al. (1991) Infect. Immun. 59:2070-2074 "Further Characterization of a Potent Immunogen and the Chromosomal Gene Encoding It in the Lyme Disease Agent, Borrelia burgdorferi".
Harlow et al. "Antibodies: A Laboratory Manual," 1988 by Cold Spring Harbor (New York), see pp. 141, 142, 516.
Lefebvre Rance B.
Perng Guey-Chen
Graser Jennifer
Housel James C.
The Regents of the University of California
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