Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-07-12
2011-11-29
Kolker, Daniel E (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
08067183
ABSTRACT:
This invention defines novel research methodology for use in (a) monitoring the ongoing status of the physiological expression of Charcot-Marie-Tooth disease and (b) screening candidate therapeutic drug agents for possible effectiveness. The presence of this neurodegenerative disease can be characterized in part by the expression in cultured fibroblasts obtained from the patient of one or more proteins which are not the product of a defective disease-inducing gene, but which are stress proteins, one or more other proteins modified by conditions of oxidative stress or other disease-related proteins. This candidate drug screening technology offers advantages in terms of (a) providing new research opportunities, (b) cost effectiveness, (c) ability to be used readily on a large scale, (d) ability to generate meaningful data in a comparatively short period of time, and (e) providing an opportunity to obtain information based on direct interaction of a candidate drug and a living tissue disease model.
REFERENCES:
patent: 4012288 (1977-03-01), Lyman et al.
patent: 95/05466 (1995-02-01), None
Sigma Cell Culture catalog 1994 edition, p. 143.
Malow 1989 (Arch Neurol 46:1201-1203).
Tesco 1992 (Mechanisms of Ageing and Development 66:117-120).
Vile 1995 (Free Radical Biology & Medicine 18(4):721-730.
Dreher 1995 (Electrophoresis 16(7):1205-1214).
Edwards 1991 (Journal of Investigative Dermatology 96:392-396).
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