Methods and compositions for determining the tumor suppressor st

Details Methods and compositions for determining the tumor suppressor st Methods and compositions for determining the tumor suppressor st

1996-05-31

1999-03-02

Feisee, Lila

Drug, bio-affecting and body treating compositions

In vivo diagnostic or in vivo test agent which contains an...

435 5, 435 6, 514 44, A01N 6300, C12Q 170, C12Q 168

Patent

active

058767118

ABSTRACT:
Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that encodes a reporter molecule and a second p53 binding polynucleotide sequence that is operably linked to the first polynucleotide sequence such that binding of p53 to the second polynucleotide sequence causes the expression of the reporter molecule which can be detected or quantified.

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Chalfie et al, Science, 1994, 263:802-805.
Wafik S. El-Deiry, et al., WAF1 a Potential Mediator of p53 Tumor Suppression, Cell, vol. 75, 817-825, Nov. 19, 1993.
Andrew J. Bett, et al., An Efficient and Flexible System for Construction of Adenovirus Vectors with Insertions or deletions in Early Regions 1 and 3, Proc. Natl. Acad. Sci. USA, vol. 91, pp. 8802-8806 Sep. 1994 Medical Sciences.
Martin Chalfie, et al., Green Fluorescent Protein as a Marker for Gene Expression, Science, vol. 263 Feb. 11, 1994.
James W. Lille, et al., Transcription activation by the adenovirus E1a protein, Nature--vol. 338 Mar. 2, 1989.

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