Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2003-12-24
2011-12-13
Gross, Christopher M (Department: 1636)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C435S006100, C435S007100, C536S023100
Reexamination Certificate
active
08076461
ABSTRACT:
An antibody microarray is described comprising a plurality of antibodies immobilized on a substrate, wherein each antibody specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having an organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are disclosed, along with cells for making such antibodies. Methods of making and using such antibody microarrays are also disclosed.
REFERENCES:
patent: 5049656 (1991-09-01), Lewis et al.
patent: 5143854 (1992-09-01), Pirrung
patent: 5221736 (1993-06-01), Coolidge et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5451463 (1995-09-01), Nelson et al.
patent: 5464759 (1995-11-01), Coolidge et al.
patent: 5489678 (1996-02-01), Fodor et al.
patent: 5510270 (1996-04-01), Fodor et al.
patent: 5571639 (1996-11-01), Hubbell et al.
patent: 5578832 (1996-11-01), Trulson et al.
patent: 5593839 (1997-01-01), Hubbell et al.
patent: 5599695 (1997-02-01), Pease et al.
patent: 5631734 (1997-05-01), Stern et al.
patent: 5703223 (1997-12-01), Wickstrom et al.
patent: 5723598 (1998-03-01), Lerner et al.
patent: 5741462 (1998-04-01), Nova et al.
patent: 5744101 (1998-04-01), Fodor et al.
patent: 5751629 (1998-05-01), Nova et al.
patent: 5800992 (1998-09-01), Fodor et al.
patent: 5871747 (1999-02-01), Gengoux-Sedlik et al.
patent: 5871928 (1999-02-01), Fodor et al.
patent: 5925562 (1999-07-01), Nova et al.
patent: 5958342 (1999-09-01), Gamble et al.
patent: 6017496 (2000-01-01), Nova et al.
patent: 6056926 (2000-05-01), Sugarman et al.
patent: 6107039 (2000-08-01), Hanna
patent: 6133444 (2000-10-01), Coull et al.
patent: 6197506 (2001-03-01), Fodor et al.
patent: 6197599 (2001-03-01), Chin et al.
patent: 6329209 (2001-12-01), Wagner et al.
patent: 6579719 (2003-06-01), Hutchens et al.
patent: 2002/0150921 (2002-10-01), Barany et al.
patent: 2003/0044831 (2003-03-01), Agris et al.
patent: 98/03532 (1998-01-01), None
patent: WO99/00402 (1999-01-01), None
patent: 01/49745 (2001-07-01), None
patent: 01/49745 (2001-07-01), None
patent: 03/003019 (2003-01-01), None
Wadkins et al (1997 J. Biomedical Optics 2:74-79).
Davis, G.E., et al., “Major and Modified Nucleosides in tRNA Hydrolysates by High Performance Liquid Chromatography”J. Chromatography, 173:281-298 (1979).
Agris and Tompson, “High-Performance Liquid Chromatography and Mass Spectrometry of Transfer RNA Bases for Isotopic Abundance”,J. Chromatography, 194:205-212 (1980).
Gehrke, C.W. et al., “Quantitative Enzymatic Hydrolysis of tRNAs: RP-HPLC of tRNA Nucleosides”,J. Chromatography, 230:297-308 (1981).
Agris and Sierzputowska-Gracz, “Three Dimensional Dynamic Structure of tRNA's by Nuclear Magnetic Resonance Spectroscopy”, Chromatography and Modification of Necleosides, pp. 225-253, Elsevier Publishing Co. (1990).
Sprinzl et al., “Compilation of tRNA Sequences and Sequences of tRNA Genes”,Nucleic Acids Res., 26, No. 1, pp. 148-153 (1998).
Huse et al., “Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda”,Science246:1275-1281 (Dec. 8, 1989).
MacBeath and Schreiber, “Printing Proteins as Microarragys for High-Throughput Function Determination”,Science, 289:1760 (Sep. 8, 2000).
Haab, B.B., et al., “Protein Microarrays for Highly Parallel Detection and Quantitation of Specific Proteins and Antibodies in Complex Solutions”,Genomebiology2(2) research 0004.1-0004.12 (Jan. 22, 2001).
Degling and Stjarnkvist, “Biodegradable Microspheres XVIII: The Adjuvant Effect of Polyacryl Starch Microparticles with Conjugated Human Serum Albumin”,Vaccine13(7):629-636 (1995).
Tortora et al., Microbiology 6thedition (1997) Addison Wesley Longman, Inc., p. 497.
Chersi et al., “Preparation of Rabbit Antibodies to 4,4′-Dimethoxytriphenylmethyl, the Protective Group in Oligonucleotide Synthesis”, Bio. Chem. Hoppe-Seyler, vol. 372, pp. 845-848, Sep. 1991.
Lehninger, Albert L., “Chapter 12 Nucleotides and the Covalent Structure of Nucleic Acids”,Biochemistry, 2ndedition (1975) New York: Worth Publishers, pp. 309-333.
Alberto Chersi et al.; “Preparation of Rabbit Antibodies to 4,4′-Dimethoxytriphenylmethyl, the Protective Group in Oligonucleotide Synthesis”, Biological Chemistry Hoppe-Seyler, Walter de Gruyter & Co, New York, vol. 372, pp. 845-848, Sep. 1991.
European Search reported dated Aug. 11, 2004.
Mitchell Lloyd G.
Pearce Christopher D. J.
Buchanan & Ingersoll & Rooney PC
Gross Christopher M
Proteome Sciences PLC
LandOfFree
Methods and compositions for determining the purity of and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for determining the purity of and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for determining the purity of and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4313347