Methods and compositions for detecting receptor-ligand...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S003000, C435S004000, C435S006120, C435S007230, C435S007240, C435S040510, C435S375000, C435S287200, C435S973000, C436S546000, C436S010000, C436S056000, C436S063000, C436S064000, C436S172000, C436S174000

Reexamination Certificate

active

07381535

ABSTRACT:
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.

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