Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2008-03-18
2008-03-18
Tucker, Zachary C (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S343000
Reexamination Certificate
active
07345172
ABSTRACT:
In accordance with the present invention there is provided a new class of sterically demanding metallo-intercalators. These compounds intercalate between bases in a duplex polynucleotide, but only where the bases are not fully complementary, for example, where there is a base-pair mismatch. The compounds are sufficiently sterically demanding that intercalation between bases in fully complementary duplexes does not occur to a significant degree. These mismatch intercalators are useful for detecting DNA and RNA defects, for diagnosing disorders characterized by the presence or increase in DNA and/or RNA defects, and for treating such disorders. Further, the compounds are capable of catalyzing photolytic cleavage of nucleic acids at relatively long wavelengths, and under normal sunlight.
REFERENCES:
patent: 5157032 (1992-10-01), Barton
patent: 5607924 (1997-03-01), Magda et al.
patent: 6031098 (2000-02-01), Barton et al.
patent: 6063573 (2000-05-01), Kayyem
patent: 6071699 (2000-06-01), Meade et al.
patent: 6087100 (2000-07-01), Meade et al.
patent: 6090933 (2000-07-01), Kayyem
patent: 6096273 (2000-08-01), Kayyem et al.
patent: 6306601 (2001-10-01), Barton et al.
patent: 6444661 (2002-09-01), Barton et al.
patent: 6777405 (2004-08-01), Barton et al.
patent: WO 86/04358 (1986-07-01), None
patent: WO 99/09203 (1999-02-01), None
Danliker et al. Biochemistry 37 :6491-6502 (1998).
The Stratagene Catalog p. 39 (1988).
Fletcher et al., “Structural, Electrochemical and UV/VIS/NIR Spectroelectrochemical Properties of Diastereomerically Pure Dinuclear Ruthenium Complexes Based on the Bridging Ligand Phenanthroline-5,6-Diimine, and a Mononuclear By-Product with a Peripheral Isoimidazole Group”,Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry, (17), 2999-3006 (1999).
Jackson & Barton, “Recognition of DNA Base Mismatches by a Rhodium Intercalator”,Journal of the American Chemical Society, 119:12986-12987 (1997).
Barton Jacqueline K.
Junicke Henrik
Calfornia Institute of Technology
DLA Piper (US) LLP
Tucker Zachary C
LandOfFree
Methods and compositions for detecting polynucleotide duplex... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for detecting polynucleotide duplex..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for detecting polynucleotide duplex... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2806934