Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-08-03
2008-07-22
Ramirez, Delia M (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S189000, C435S320100, C435S091200, C435S026000, C536S023100, C536S023200, C536S023500, C530S350000, C436S094000
Reexamination Certificate
active
07402387
ABSTRACT:
The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.
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patent: WO 97/35034 (1997-09-01), None
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Vreken, P. et al., “A point mutation in an invariant splice donor site leads to exon skipping in two unrelated Dutch patients with dihydropyrimidine dehydrogenase deficiency,”J. Inherit. Metab. Dis., 19(5):645-54 (1996).
Wei, X. et al. “Molecular Basis of the Human Dihydropyrimidine Dehydrogenase Deficicency and 5-Fluorouracil Toxicity,”J. Clin. Invest., 98(3)610-615 (1996).
Yokota, Hiroshi et al.: “cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, and enzyme associated with 5-flouorouracil toxicity and congenital thymine uracilura”; J. Biological Chemistry, vol. 269, No. 37; pp. 23192-23196 (Sep. 16, 1994).
OMIM Entry for “Dyhydropyrimidine Dehydrogenase; DPYD” printed on Dec. 3, 2003.
Fernandez-Salguero Pedro
Gonzalez Frank J.
Ramirez Delia M
The United States of America as represented by the Department of
Townsend and Townsend / and Crew LLP
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