Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-06-21
2011-06-21
Babic, Christopher M. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
07964353
ABSTRACT:
This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.
REFERENCES:
patent: 5786146 (1998-07-01), Herman et al.
patent: 6017704 (2000-01-01), Herman et al.
patent: 6200756 (2001-03-01), Herman et al.
patent: 6265171 (2001-07-01), Herman et al.
patent: 7485420 (2009-02-01), Markowitz
patent: 2003/0148327 (2003-08-01), Olek et al.
patent: 2004/0048279 (2004-03-01), Olek et al.
patent: WO 97/46705 (1997-12-01), None
patent: WO-01/77373 (2001-10-01), None
patent: WO-01/77376 (2001-10-01), None
patent: WO0177376 (2001-10-01), None
patent: WO-02/18632 (2002-03-01), None
patent: WO 02/38801 (2002-05-01), None
Kusinska et al. J Exp Clin Cancer Res. Aug. 20, 2009;28:118.
Prudkin et al. Mod Pathol. May 2009;22(5):668-78.
Lange et al. (J Cell Sci. Oct. 2000;113 Pt 19:3463-72).
Chen et al. (Natl Cancer Inst. Aug. 3, 2005;97(15):1124-32).
Baylin and Bestor (Cancer Cell. May 2002;1(4):299-305).
Lucentini et al (The Scientist (2004) vol. 18).
Wacholder et al (J. Natl. Cancer Institute (2004) 96(6):434-442).
Domagala et al (Am J Pathol. Jan. 1990;136(1):219-27).
Lagendijk et al (Clin Pathol. Apr. 1999;52(4):283-90).
Herman et al. (“Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands” Proc Natl Acad Sci U S A. Sep. 3, 1996;93(18):9821-6).
Attwood, J.T. et al. DNA methylation and the regulation of gene transcription. Cell Mol. Life Sci. 59, 241-257 (2002).
Baylin, S., et al., “Altered methylation patterns in cancer cell genomes: Cause or consequence?,” Cancer Cell, 1:299-305 (2002).
Baylin, S.B. et al. Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia. Adv. Cancer Res., 72, 141-96 (1998).
Chen, et al., Natl. Cancer Inst., 97(15):1124-32 (2005).
Costello, J.F. et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat. Genet. 24, 132-8 (2000).
Domagala, W., et al., “Vimentin Is Preferentially Expressed in Human Breast Carcinomas With Low Estrogen Receptor and High Ki-67 Growth Fraction,” American Journal of Pathology, 136(1):219-227 (1990).
Eden, S., et al., “Role of DNA methylation in the regulation of tanscription,” Current Opinion in Genetics and Development, 4(2):255-259 (1994).
Evans, R.M., et al., “Vimentin: the conundrum of the intermediate filament gene family,” BioEssays, 20:79-86 (1998).
Gonzalez-Zulueta, M. et al. Methylation of the 5′ CpG Island of the p16/CDKN2 Tumor Suppressor Gene in Normal and Transformed Human Tissues Correlates with Gene Silencing. Cancer Res. 55, 4531-4535 (Oct. 15, 1995).
Gonzalgo, M.L. and Jones, P.A. Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE). Nucleic Acids Res. 25, 2529-31 (1997).
Grady, W.M. et al. Detection of Aberrantly Methylated hMLH1 Promoter DNA in the Serum of Patients with Microsatellite Unstable Colon Cancer. Cancer Res. 61, 900-2 (2001).
Herman, J.G. et al. Inactivation of the CDKN2/p16/MTS1 Gene is Frequently Associated with Aberrant DNA Methylation in all Common Human Cancers. Cancer Res. 55, 4525-4530 (1995).
Herman, J.G., et al., “Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands,” PNAS 93:9821-9826 (1996).
Hibi, K. et al. Molecular Detection of Genetic Alterations in the Serum of Colorectal Cancer Patients. Cancer Res. 58, 1405-7 (1998).
Izmailova, E. S. et al., “A GC-box is required for expression of the human vimentin gene”, Gene, 235(1-2) p. 69-75 (1999).
Jeronimo, C. et al. Quantitation of GSTP1 Methylation in Non-neoplastic Prostatic Tissue and Organ-Confined Prostate Adenocarcinoma. J. Natl. Cancer Inst. 93, 1747-1752 (2001).
Jones, P.A. et al. The DNA methylation paradox. Trends Genet. 15, 34-7 (1999).
Kane, M.F. et al. Methylation of the hMLH1 Promoter Correlates with Lack of Expression of hMLH1 in Sporadic Colon Tumors and Mismatch Repair-defective Human Tumor Cell Lines. Cancer Res. 57, 808-11 (1997).
Lagendijk, et al., Clin. Pathol., 52(4):283-290 (1999).
Lange, F., et al., “Teratocarcinomas induced by embryonic stem (ES) cells lacking vimentin: An approach to study the role of vimentin in tumorigenesis,” Journal of Cell Science, 113(19):3463-3472 (2000).
Li, H. et al. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. PNAS 100(14), 8412-7 (2003).
Lucentini, et al., The Scientist, vol. 18 (2004).
Markowitz, S. et al. Inactivation of the Type II TGF-$\beta$ Receptor in Colon Cancer Cells with Microsatellite Instability. Science 268, 1336-1338 (1995).
Moinova, H.R. et al. HLTF gene silencing in human colon cancer. PNAS 99, 4562-7 (2002).
Paramio, J.M., et al., “Beyond structure: do intermediate filaments modulate cell signalling?,” BioEssays, 24:836-844 (2001).
Petko, Zsolt, et al., “Aberrantly methylated CDKN2A, MGMT and hMLH1 are biomarkers for colon adenomas and colon adenocarcinomas”, Proceedings of the American Association for Cancer Research Annual Meeting, 44, pp. 698 (2003).
Usadel, H. et al. Quantitative Adenomatous Polyposis Coli Promoter Methylation Analysis in Tumor Tissue, Serum, and Plasma DNA of Patients with Lung Cancer. Cancer Res. 62, 371-5 (2002).
Veigl, M.L. et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. PNAS 95, 8698-702 (1998).
Wacholder, et al., J. Natl. Cancer Institute, 96(6):434-442 (2004).
Willson, J.K.V. et al. Cell Culture of Human Colon Adenomas and Carcinomas. Cancer Res. 47, 2704-2713 (1987).
Xiong, Z. and Laird, P.W. Cobra: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 25, 2532-4 (1997).
Breivik and Gaudernack, “Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis,” Cancer Biology, vol. 9, pp. 245-254 (1999).
Fraga and Esteller, “DNA Methylation: A Profile of Methods and Applications,” BioTechniques, vol. 33, pp. 632, 634, 636-649 (2002).
Issa, Jean-Pierre, “The Epigenetics of Colorectal Cancer,” Ann. N.Y. Acad. Sci., vol. 910, pp. 140-155 (2000).
McClelland and Nelson, “The effect of site-specific DNA methylation on restriction endonucleases and DNA modification methyltransferases—a review,” Gene, vol. 74, pp. 291-304 (1988).
“Short Technical Reports: Quantification of 5-Methylcytosine in DNA by the Chloroacetalde-hyde Reaction,” Biotechniques, vol. 27, pp. 744-752 (1999).
Babic Christopher M.
Case Western Reserve University
Ropes & Gray LLP
LandOfFree
Methods and compositions for detecting colon cancers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for detecting colon cancers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for detecting colon cancers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2672332