Methods and compositions for detecting anti-hepatitis E virus ac

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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436820, 530326, 530328, C12Q 170, G01N 33576, C07K 1408

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057363153

ABSTRACT:
The present invention provides antigenic peptides and polypeptides of hepatitis E virus. Also provided are mixtures of conjugated and unconjugated peptides of the present invention. Methods of detecting hepatitis E viral infection in a subject using the peptides and peptide mixtures of the present invention are also contemplated.

REFERENCES:
Goldsmith et al. The Lancet 339:328-331, 1992.
Tam et al. Virology 185:120-131, Nov. 1991.
Yarbough et al. J. Virol. 65:5790-5796, Aug. 1991.
Ichikawa et al. Microbiol. Immunol. 35(7):535-543, Apr. 1991.
Reyes et al. Gastroenterologia Japonica 26(3):142-147, 1991.
Reyes et al. Viral Hepatitis C, D and E Elsevier Sci. Pub. B.V. (Biomed. Div.), chapter 43, pp. 237-245, 1991.
Reyes et al. Science 245:1335-1339, Mar. 1990.
Bradley et al. Proc. Natl. Acad. Sci. USA 84:6277-2681, May 1987.
Kaur et al., Human linear B-cell epitopes encoded by the hepatitis E virus include determinants in the RNA-dependent RNA polymerase. Proc. Natl. Acad. Sci. 89:3855-3858, 1992.
Favorov et al., Abstract #1662, Abstracts of the 1992 ICAAC, "Peptide EIA for detection of antibody to hepatitis E virus," p. 388.
Dawson et al., Journal of Virological Methods 38:175-186 (1992).

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