Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-02-15
1997-04-08
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
434558, C07K 14435, A01K 3817
Patent
active
056189176
ABSTRACT:
An autocrine crystal adhesion inhibitor called CAI is an anionic, sialic acid-containing glycoprotein secreted by kidney epithelial cells that blocks adhesion of calcium oxalate monohydrate (COM) crystals to the cell surfaces. Persons may be classified according to risk of developing kidney stones, by measuring the amount of CAI in a biological sample. Treatment efficacy is also monitored by this method. CAI is administered in vivo to prevent nephrolithiasis. A rapid, simple assay to detect agents that inhibit adhesion of COM crystals to the surface of kidney epithelial cells is characterized.
REFERENCES:
Lieske, John C., Rebbecca Leonard, and F. Gary Toback (1995). Adhesion of calcium oxalate monohydrate crystals to renal epithelia cells is inhibited by specific anions, American Physiological Society, pp. F604-F612.
Lieske, John C. and F. Gary Toback (1993). Regulation of renal epithelial cell endocytosis of calcium oxalate monohydrate crystals, American Physiological Society, pp. F800-F807.
Lieske, John C., Margaret M. Walsh-Reitz, and F. Gary Toback (1992). Calcium oxalate monohydrate crystals are endocytosed by renal epithelial cells and induce proliferation, American Physiological Society, pp. F622-F630.
Riese, Richard J., Neil S. Mandel, John H. Wiessner, Gretchen S. Mandel, Carl G. Becker, and Jack G. Kleinman (1992). Cell polarity and calcium oxalate crystal adherence to cultured collecting duct cells, Am. J. Physiol, 262, pp. F177-F184.
Nakagaya, Yasushi, Veronika Abram, Ferenc J. Kezdy, Emil Thomas Kaiser and Frederic L. Coe (1983). Purification and Characterization of the Principal Inhibitor of Calcium Oxalate Monohydrate Crystal Growth in Human Urine, The Journal of Biological Chemistry, vol. 258, No. 20, Issue of Oct. 25, pp. 12594-12600.
Hess, Bernhard, Yasushi Nakagaya and Frederic L. Coe (1989). Inhibition of Calcium oxalate monohydrate crystal aggregation by urine proteins, Am. J. Physiol. 257; F99-106.
Wiessner, John H., Jack G. Kleinman, Samuel S. Blumenthal, John C. Garancis, Gretchen S. Mandel and Neil S. Mandel (1987). Calcium oxalate crystal interaction with rat renal inner papillary collecting tubule cells, The Journal of Urology, vol. 134, pp. 640-643.
Riese, Richard J., Jerome W. Riese, Jack G. Kleinman, John H. Wiessner, Gretchen S. Mandel and Neil S. Mandel ( ). Specificity in calcium oxalate adherence to papillary epithelial cells in culture, Am. J. Physiol. pp. F0125-F1032.
Lieske, John C, Hewson Swift, Terrence Martin, Briong Patterson and F. Gary Toback Jul. 1994 Proc. Natl. Acad Sci USA vol. 91: 6987-6991.
Lieske John C.
Toback F. Gary
ARCH Development Corporation
Nucker Christine M.
Reeves Julie E.
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