Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2004-12-03
2008-11-11
Ton, Thaian N. (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S455000, C435S320100, C435S325000
Reexamination Certificate
active
07449563
ABSTRACT:
Polypeptides that comprise an approximately 100-amino acid residue region of a centrosomal P4.1-associated protein (CPAP) that possess microtubule-destabilizing activity, polynucleotides encoding such polypeptides, compositions comprising the polypeptides and polynucleotides, and methods of use thereof, are disclosed. The invention is useful for destabilizing microtubules in eukaryotic cells, including but not limited to cancer cells.
REFERENCES:
patent: 2003/0032771 (2003-02-01), Sharp et al.
patent: 2003/0050233 (2003-03-01), Burman et al.
patent: 2003/0083261 (2003-05-01), Yu et al.
USPTO Sequence search results for SEQ ID No. 1, identifying portions of AL833182 and BG259304 as being 100% identical to amino acids 311-422 of SEQ ID No. 1.
GenBank Deposit with accession code for AL833182.
GenBank Deposit with accession code for BG259304.
Ngo et al., 1994, The protein Folding Problem and Tertiary Structure Prediction, pp. 491-495.
Hung et al Mol. Cell. Biol, 1998, 20 (2), 7813-7825.
NCBI accession No. AF 139625, dated Oct. 5, 2000.
Ecke et al Goodman & Gilman's The Pharmacological basis of Therapeutics, McGraw-Hill, New York, NY. 1996, pp. 77-101.
Verma and Somia (1997) Nature 389:239-242.
Verma (2005) Annu Rev Biochem. 2005;74:711-38.
Vile et al Gene Therapy, 2000, 7: 2-8.
Belmont, L.D. and Mitchison, T.J. (1996). Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules.Cell, 84, 623-631.
Cassimeris, L. and Spittle, C. (2001). Regulation of microtubule-associated proteins.Int. Rev. Cytol., 210, 163-226.
Cassimeris, L. (2002). The oncoprotein18/stathmin family of microtubule destabilizers.Curr. Opin. Cell. Biol., 14, 18-24.
Conboy, J.G., et al. (1988). Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells.Proc. Natl. Acad. Sci. USA, 85, 9062-9065.
Conboy, J.G., et al. (1991). Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1.J. Biol. Chem., 266, 8273-8280.
DeCárcer, G., et al. (1995). Protein 4.1 is a component of the nuclear matrix of mammalian cells.Biochem J., 312 (Pt 3), 871-877.
Desai, A., et al. (1999). Kin I kinesins are microtubule-destabilizing enzymes.Cell, 96, 69-78.
Erickson, H.P. and Stoffler, D. (1996). Protofilaments and rings, two conformations of the tubulin family conserved from bacterial FtsZ to α/β and γ tubulin.J. Cell. Biol., 135, 5-8.
Hartman, J.J., et al. (1998). Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.Cell, 93, 277-287.
Heald, R. and Nogales, E. (2002). Microtubule dynamics.J. Cell Sci., 115, 3-4.
Huang, J.P., et al. (1993). Genomic structure of the locus encoding protein 4.1. Structural basis for complex combinational patterns of tissue-specific alternative RNA splicing.J. Biol. Chem., 268, 3758-3766.
Hung, L.Y., et al. (2000). Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the γ-tubulin complex.Mol. Cell Biol., 20, 7813-7825.
Hung, L.Y. and Tang, T.K. (2002). A novel centrosomal protein (CPAP) play a role in cell mitosis and genomic stability. Page 115, Program & Abstracts, the 4thAsian-Pacific Organization for Cell Biology Congress, Nov. 3-6, 2002.
Krauss, S.W., et al. (1997). Structural protein 4.1 in the nucleus of human cells: dynamic rearrangements during cell division.J. Cell Biol., 137, 275-289.
Krauss, S.W., et al. (1997). Structural protein 4.1 is located in mammalian centrosomes.Proc. Natl. Acad. Sci. USA, 94, 7297-7302.
Mattagajasingh, S.N., et al. (1999). A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein.J. Cell Biol., 145, 29-43.
McCabe, P.M., et al. (1999). The influence of dsRNA viruses on the biology of plant pathogenic fungi.Trends Microbial., 7:377-81.
McNally, F.J. and Vale, R.D. (1993). Identification of katanin, an ATPase that severs and disassembles stable microtubules.Cell, 75, 419-429.
Peng, B., et al. (2002). CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity.Mol. Endocrinol., 16, 2019-2033.
Pérez-Ferreiro, C.M., et al. (2001). 4.1R proteins associate with interphase microtubules in human T cells: a 4.1R constitutive region is involved in tubulin binding.J. Biol. Chem., 276, 44785-44791.
Rao, J.S. (2003). Molecular mechanisms of glioma invasiveness: the role of proteases.Nat. Rev. Cancer, 3:489-501.
Rochefort, H., et al. (1990). Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications.Cancer Cells, 2:383-88.
Schiebel, E. (2000). γ-tubulin complexes: binding to the centrosome, regulation and microtubule nucleation.Curr. Opin. Cell Biol., 12, 113-118.
Tang, T.K., et al. (1988). Selective expression of an erythroid-specific isoform of protein 4.1.Proc. Natl. Acad. Sci. USA, 85, 3713-3717.
Tang, T.K., et al. (1990). Heterogeneity of mRNA and protein products arising from the protein 4.1 gene in erythroid and nonerythroid tissues.J. Cell Biol., 110, 617-624.
Todd, S., et al. (2000). HIV protease as a target for retrovirus vector-mediated gene therapy.Biochim. Biophys. Acta., 1477(12):168-188.
Walczak, C.E., et al. (1996). XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly.Cell, 84, 37-47.
Zheng, Y., et al. (1995). Nucleation of microtubule assembly by a γ-tubulin-containing ring complex.Nature, 378, 578-583.
Chang Ching-Wen
Hung Liang-Yi
Tang Tang K.
Academia Sinica
Occhiuti Rohlicek & Tsao LLP
Singh Anoop
Ton Thai-an N.
LandOfFree
Methods and compositions for destabilizing microtubules does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for destabilizing microtubules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for destabilizing microtubules will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4028578