Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Reexamination Certificate
2006-11-28
2006-11-28
Richter, Johann (Department: 1616)
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
C424S450000, C424S491000, C424S493000
Reexamination Certificate
active
07141236
ABSTRACT:
Methods and compositions for delivering macromolecules to or via the respiratory tract, such that the macromolecules exhibit improved local and/or systemic bioavailability are provided. Such methods utilize lipid-based microstructures formed in combination with at least one bioactive macromolecule, which have a superior ability to rapidly release the bioactive macromolecule(s) thereby resulting in improved local and/or systemic bioavailability of the bioactive macromolecule(s). Such improved bioavailability is believed to be due, in part, to reduction of scavenging by bronchoalveolar macrophages and/or mucociliary clearance. Compositions with improved bioavailability are provided comprising a plurality of lipid-based microstructures formed in combination with at least one bioactive macromolecule, wherein the bioavailability of the bioactive macromolecule is improved by modifying the rate of release of the bioactive macromolecule from the microstructure thereby reducing scavenging by bronchoalveolar macrophages and/or mucociliary clearance.
REFERENCES:
patent: 5043158 (1991-08-01), Sleytr et al.
patent: 5308620 (1994-05-01), Yen
patent: 5616311 (1997-04-01), Yen
patent: 5759572 (1998-06-01), Sugimoto et al.
patent: 5807552 (1998-09-01), Stanton et al.
patent: 5855913 (1999-01-01), Hanes et al.
patent: 5985309 (1999-11-01), Edwards et al.
patent: 6071497 (2000-06-01), Steiner et al.
patent: 0 274 431 (1988-07-01), None
patent: 0 372 777 (1990-06-01), None
patent: 0 611 567 (1994-08-01), None
patent: 88 01862 (1988-03-01), None
patent: 99/16419 (1999-04-01), None
patent: 99/16420 (1999-04-01), None
patent: 99/16421 (1999-04-01), None
patent: 99/16422 (1999-04-01), None
patent: 00/00215 (2000-01-01), None
patent: 01/13891 (2001-03-01), None
patent: 01/85136 (2001-11-01), None
patent: 01/85137 (2001-11-01), None
Johnson, Preparation of peptide and protein powders for inhalation, Advanced Drug Delivery Reviews 26 (1997) 3-15
Mitra et al, Enhanced Pulmonary Delivery of Insulin by Lung Fluid and Phospholipids, International Journal of Pharmaceutics 217 (2001) 25-31.
International Search Report, PCT/US02/13145, issued Aug. 20, 2002.
Bot Adrian I.
Dellamary Luis A.
Smith Dan J.
Haghighatian Mina
Janah Ashok K.
Nektar Therapeutics
Richter Johann
Tucker Guy
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