Coating processes – Medical or dental purpose product; parts; subcombinations;... – Implantable permanent prosthesis
Reexamination Certificate
2005-05-31
2005-05-31
Seidleck, James J. (Department: 1711)
Coating processes
Medical or dental purpose product; parts; subcombinations;...
Implantable permanent prosthesis
C433S202100, C433S204000, C264S019000, C523S115000
Reexamination Certificate
active
06899915
ABSTRACT:
Tooth tissues include the pulp mesenchyme that forms the dentin and an epithelium that is responsible for enamel formation. Cells from these tissues were obtained from porcine third molars and were seeded onto a biodegradable scaffold composed of a polyglycolic acid—polylactic acid copolymer. Cell polymer constructs were then surgically implanted into the omentum of athymic nude rats so that the constructs would have a blood supply and these tissues were allowed to develop inside the rats. Infrequently, columnar epithelial cells were observed as a single layer on the outside of the dentin-like matrix similar to the actual arrangement of ameloblasts over dentin during early tooth development. Developing tooth tissues derived from such cell polymer constructs could eventually be surgically implanted into the gum of an edentulous recipient where the construct would receive a blood supply and develop to maturity, providing the recipient with a biological tooth replacement.
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Bartlett John D.
Olsen Bjorn R.
Stashenko Phillip
Vacanti Joseph P.
Yelick Pamela C.
Banner & Witcoff , Ltd.
Bissett Melanie
Forsyth Dental Infirmary for Children, Inc.
General Hospital Corporation
Seidleck James J.
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