Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2004-06-02
2008-12-02
Schnizer, Richard (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S025300
Reexamination Certificate
active
07459547
ABSTRACT:
Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number of mismatches tolerated, the effect of the position of the mismatches, etc. Such rules are useful, in particular, in the design of improved RNAi-mediating agents which allow for more exact control of the efficacy of RNA silencing.
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Tang Guiliang
Zamore Phillip D.
Lahive & Cockfield LLP
Milasincic Esq. Debra J.
Schnizer Richard
University of Massachusetts
Velema James H.
LandOfFree
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