Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-09-29
1999-05-11
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514211, 514212, 514218, 5142388, 514247, 514255, 514256, 514315, 514359, 514374, 514378, 514396, 514399, 514400, 514408, 514428, 504150, A61K31/535
Patent
active
059028084
ABSTRACT:
The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one N-alkyl heterocyclic compound to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one N-alkyl heterocyclic compound to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The N-alkyl heterocyclic compound used in the method of the invention has the following formula: ##STR1## The substituent R.sup.1 is a C.sub.8 -C.sub.20 alkyl group. The heterocyclic ring is a 5-8 membered heterocyclic ring where X is O, NH, or CH.sub.2. R.sup.2 is methyl, hydroxymethyl, or hydroxyethyl. The integer n ranges from 0 to 3. The present invention also relates to a composition containing N-alkyl heterocyclic compounds and useable in the above methods. The compositions comprise at least one N-alkyl heterocyclic compound in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
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Bryant Stephen D.
Glover Daniel E.
Steelhammer Joe C.
Whittemore Marilyn S.
Buckman Laboratories International Inc.
Robinson Allen J.
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