Methods and compositions for cancer detection

Details Methods and compositions for cancer detection Methods and compositions for cancer detection

1981-06-02

1984-12-18

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

260112R, 260112B, 424 11, 424 85, 436531, 436543, 436544, 436545, 436546, 436547, 436800, 436804, 436813, G01N 3354, G01N 3356, G01N 3358, A61K 4300

Patent

active

044891679

ABSTRACT:
Carcinoembryonic antigen contains immune determinates in common with .alpha.-acid glycoprotein. Carcinoembryonic antigen-containing compositions are purified by adsorption onto antibody to .alpha.-acid glycoprotein. The purified compositions may be employed as standards in carcinoembryonic antigen assays or in the labelled form as tracers. Intact carcinoembryonic antigen is assayed by a modified sandwich-type immunoassay. Other cancer-associated substances may be identified by searching for high molecular weight analogues of normal proteins.

REFERENCES:
patent: 3960827 (1976-06-01), Bjorklund
patent: 4075194 (1978-02-01), Sela et al.
patent: 4132769 (1979-01-01), Osther
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patent: 4178285 (1979-12-01), Felts et al.
patent: 4180499 (1979-12-01), Hansen
patent: 4198389 (1980-04-01), Wadsworth
Barbotte et al., Chemical Abstracts, vol. 86, 1977, Abstract #87384a.
Miyazaki et al., Clinica Chimica Acta, 122, (1982), 161-168.

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