Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-10-25
1998-09-22
Carlson, Karen
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530350, C12Q 100, G01N 3353, C07K 1400
Patent
active
058112430
ABSTRACT:
A method of combatting Alzheimer's disease which comprises increasing the binding of the tau protein in nerve cells of that subject, and/or the binding of MAP2c protein in nerve cells of that subject, to either Apolipoprotein E or an Apolipoprotein E fragments capable of binding tau and/or MAP2c. In one embodiment, the method comprises administering the ApoE or ApoE fragment to the subject; in another embodiment, the method comprises administering to the subject a vector capable of entering nerve cells, which vector then upregulates the expression of an ApoE or an ApoE fragment capable of binding tau and/or MAP2c in nerve cells. Compositions useful for carrying out these methods are also disclosed.
REFERENCES:
Moraga et al 1992 Biochim. Biophys. Acta 1121 (1-2) 97-103 Abstract only.
Strittmatter et al 1994 PNAS 91:11183-11186.
Goedert Michel
Roses Allen D.
Saunders Ann M.
Schmechel Donald E.
Strittmatter Warren J.
Carlson Karen
Duke University
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