Methods and compositions for attenuating antibody-mediated xenog

Details Methods and compositions for attenuating antibody-mediated xenog Methods and compositions for attenuating antibody-mediated xenog

1995-06-02

1997-12-09

Saunders, David

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Extracorporeal or ex vivo removal of antibodies or immune...

536 41, 536 172, 536 221, 536 552, C07H 304, C07H 306, C07H 506

Patent

active

056957599

ABSTRACT:
Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by extracorporeal perfusion of the recipient's blood over a biocompatible solid support to which the xenoantigens are bound and/or (2) parenterally administering a xenoantibody-inhibiting amount of an identified xenoantigen to the recipient shortly before graft revascularization and thereafter.

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