Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Extracorporeal or ex vivo removal of antibodies or immune...
Patent
1992-08-21
1997-07-29
Saunders, David
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Extracorporeal or ex vivo removal of antibodies or immune...
530413, 604 5, 604 6, A61K 3900, A61M 3700
Patent
active
056519680
ABSTRACT:
Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by extracorporeal perfusion of the recipient's blood over a biocompatible solid support to which the xenoantigens are bound and/or (2) parenterally administering a xenoantibody-inhibiting amount of an identified xenoantigen to the recipient shortly before graft revascularization and thereafter.
REFERENCES:
patent: 4137401 (1979-01-01), Lemieux et al.
patent: 4238473 (1980-12-01), Lemieux et al.
patent: 4362720 (1982-12-01), Lemieux et al.
patent: 5079353 (1992-01-01), Ratcliffe et al.
Abbas, et al., "Tumor-Associated Oligosaccharides II: Synthesis of Sialyl-X Antigenic Determinant", Proc. Japanese-German Symp. Berlin, pp. 20-21 (1988).
Agishi, et al., "Double Filtration Plasmapheresis", Trans. Am. Soc. Artif. Internal Organs, vol. XXVI, pp. 406-409 (1980).
Alexandre, et al., "Plasmapheresis and splenectomy in experimental renal xenotrasplantation", Xenograft, 25, pp. 259-266 (1989).
Alexandre, et al., "Present Experiences in A Series of 26 ABO-Incompatible Living Donor Renal Allografts", Transpl. Proc., vol. XIX, No. 6, pp. 4538-4542 (Dec. 1987).
Amvam-Zollo, et al., "Streptococcus pneumoniae Type XIV Polysaccharide: Synthesis of A Repeating Brached Tetrasaccharide With Dioxa-Type Spacer-Arms*", Carbohydr. Res., vol. 150, pp. 199-212 (1986).
Bannett, et al., "Experiences With Known ABO-Mismatched Renal Transplants", Transpl. Proc., vol. XIX, No. 6, pp. 4543-4546 (Dec. 1987).
Bensinger, et al., "In Vitro and In Vivo Removal of Anti-A Erythrocyte Antibody by Adsorption to a Synthetic Immunoadsorbent", Transfusion, vol. 21, No. 3, pp. 335-342 (May-Jun. 1981).
Bensinger, et al., "ABO-Incompatible Marrow Transplants" Transpl., vol. 33, No. 4, pp. 427-429 (1982).
Bensinger, et al., "Whole Blood Immunoadsorption of Anti-A or Anti-B Antibodies", Vox Sang, 48, pp. 357-361 (1985).
Bier, et al., "Selective Plasmapheresis in Dogs For Delay of Heterograft Response", Trans. Amer. Soc. Artif. Internal Organs, vol. XVI, pp. 325-333 (1970).
Caves, et al., "Hyperacute Rejection of Orthotopic Cardiac Allografts in Dogs Following Solubilized Antigen Pretreatment.sup.1 ", Transpl., vol. 16, No. 3, pp. 252-256 (1973).
Chernyak, et al., "A New Type of Carbohydrate-Containing Synthetic Antigen: Synthesis of Carbohydrate-Containing Polyacrylamide Copolymers Having The Specificity of 0:3 And 0:4 Factors Of Salmonella", Carbohydr. Res., vol. 128, pp. 269-282 (1984).
Chien, et al., "Isolation and characterization of a heptaglycosylceramide from bovine erythrocyte membranes", J. of Lipid Res., vol. 20, pp. 669-673 (1979).
Cooper, et al., "Effects of Cyclosporine and Antibody Adsorption on Pig Cardiac Xenograft Survival in the Baboon", J. Heart Transpl. 7, pp. 238-246 (1988).
Cox, et al., "A New Synthesis of 4-O-.alpha.-D-Galactopyranosyl-D-Galactopyranose", Carbohy. Res., vol. 62, pp. 245-252 (1978).
Dahmen, et al., "2-Bromoethyl glycosides*: applications in the synthesis of spacer-arm glycosides", Carbohydr. Res., vol. 118, 292-301 (1983).
Dahmen, et al., "Synthesis of Spacer-Arm, Lipid, and Ethyl Glycosides of The Trisaccharide Portin [.alpha.-D-Gal.(1.fwdarw.4).beta.-D-Gal-(1.fwdarw.4)-.beta.-D-Glc] of The Blood-Group P.sup.K Antigen: Preparation of Neoglycoproteins", Carbohy. Res., vol. 127, pp. 15-25 (1984).
Dubois, et al., "Colorimetric Method For Determination of Sugars and Related Substances", Analytical Chem., vol. 28, No. 3, pp. 350-356 (1956).
Egge, et al., "Immunochemistry of l/i-active Oligo-and Polyglycosylceramides from Rabbit Erythrocyte Membranes", J. Biol. Chem., vol. 260, pp. 4927-4935 (1985).
Ekborg, et al., "Synthesis of Three Disacchrides For The Preparation of Immunogens Bearing Immunodeterminants Known To Occur on Glycoptroteins", Carbohydr. Res., vol. 110, pp. 55-67 (1982).
Eto, et al., "Chemistry of Lipid of the Posthemolytic Residue or Stroma of Erythrocytes", J. Biochem., vol. 64, No. 2, pp. 205-213 (1968).
Fernandez-Santana, et al., "Glycosides of Monoallyl Diethylene Glycol. A New Type of Spacer Group For Synthetic Oligosaccharides", J. Carbohydr. Chem., vol. 8, pp. 531-537 (1989).
Fischel, et al., "Prolonged Survival of a Discordant Cardiac Xenograft in a Rhesus Monkey", Transpl. Proc., vol. 23, No. 1, pp. 589-590 (Feb. 1991).
Fugedi, et al., "Thioglycosides as Glycosylating Agents in Oligosaccharide Synthesis", Glycoconj. J., vol. 4, pp. 97-108 (1987).
Galili, et al., "Evolutionary relationship between the natural anti-Gal antibody and the Gal.alpha.1.fwdarw.3Gal epitope in primates", Proc. Natl. Acad. Sci. USA, vol. 84, pp. 1369-1373 (Mar. 1987).
Galili, et al., "Human Natural Anti-.alpha.-Galactosyl IgG", J. Exp. Med., vol. 162, pp. 573-582 (Aug. 1985).
Galili, et al., "Man, Apes and Old World Monkeys Differ from other Mammals in the Expression of .alpha.-Galactosyl Epitopes on Nucleated Cells", J. of Biol. Chem., vol. 263, No. 33, pp. 17755-17762 (1988).
Garegg, et al., "A synthesis of 8-methoxycarbonyloct-1-yl O-.alpha.-D-Galactopyranosyl-(1.fwdarw.3)-O-.beta.-D-Galactopyranosyl-(1.f wdarw.4)-2-Acetamido-2-Deoxy-.beta.-D-Glucopyranoside", Carbohy. Res., vol. 136 pp. 207-213 (1985).
Garegg, et al., "Synthesis of 6-and 6'-deoxy derivatives of methyl 4-O-.alpha.-D-galactopyranosyl-.beta.-D-galactopyranoside for studies of inhibition of pyelonephritogenic fimbriated E. coli adhesion to urinary epithelium-cell surface" Carbohy. Res. vol. 137, pp. 270-275 (1985).
Ghilchik, et al., "Platelet Trapping by Sheep Kidney and Heart Xenografts in the Dog", J. of Surgical Res., vol. 17, pp. 434-440 (1974).
Giles, et al., "Mechanism and Modification of Rejection of Heterografts Between Divergent Species", Transpl. Proc., vol. II, No. 4, pp. 522-537 (Dec. 1970).
Holgersson, et al., "Carbohydrate Antigen Specificity of Pig Lymphocytotoxic IGM Antibodies Produced by the Two EBV Transformed Human B Cell lines", Glycoconjugate J. vol. 8, No. 3, p. 172 (1991).
Holgersson, et al., "Structural Characterization of Non-Acid Glycosphingolipids in Kidneys of Single Blood Group O and A Pigs", J. Biochem., vol. 108, pp. 766-777 (1990).
Jacquinet, et al., "Synthesis of Blood-group Substances Part 11. Synthesis of the Trisaccharide O-.alpha.-D-galactopyranosyl-(1.fwdarw.3)-O-.beta.-D-Galactopyranosyl-(1.f wdarw.4)-2-Acetamido-2-Deoxy-.beta.-D-Glucopyranose", J. Chem. Soc. [Perkin I], pp. 326-330 (1981).
Kameyama, et al., "Total synthesis of sialyl Lewis X*", Carbohydr. Res., vol. 209, C.sub.1 -C.sub.4 (1991).
Killion, "Carbohydrate interference of complement-dependent cell lysis", Experientia, vol. 43, pp. 327-329 (1987).
Koike, et al., "Total synthesis of Globotriaosyl-E and Z-Ceramides and Isoglobotriaosyl-E-ceramide", Carbohy. Res. vol. 163, pp. 189-208 (1987).
Lalezari, et al., "Carbohydrate-Specific Antibodies in Normal Human Sera", Vox Sang. vol. 47, pp. 133-145 (1984).
Laus, et al., "Carbohydrate-Specific Human Heterophile Antibodies in Normal Human Sera that React with Xenographic Cells", Int. Archs. Allergy Appl. Immun., vol. 85, pp. 201-207 (1988).
Lee, et al., "Synthesis of 3-(2-Aminoethylthio)Propyl Glycosides", Carbohydr. Res., vol. 37, 193 et seq. (1974).
Linn, et al., "Renal Xenograft Prolongation by Suppression of Natural Antibody", J. of Surgical Res. vol. 8, No. 5, pp. 211-213 (1968).
MacDonald, et al., "ABO-Incompatible Living Related Donor Kidney Transplantation: Report of Two Cases", Transpl. Proc., vol. 21, No. 2, pp. 3362-3363 (Apr. 1989).
McAlack, et al., "Delayed Hyperacute Rejection in an ABO-Incompatible Renal Transplant", Transpl. Proc., vol. XIX, No. 6, pp. 4558-4560 (Dec. 1987).
Merkel et al., "Modification of Xenograft Response by Selective Plasmaphresis", Transpl. Proc., vol. III, No. 1, pp. 534-537 (Mar. 1971).
Moberg, et al., "Prolongation of Renal Xenografts by the Simultaneous Sequestration of Preformed Antibody, Inhibition of Complement, Coagulation and Antibody Synthesis", Transpl. Proc., vol. III, No. 1, pp. 538-541 (1971).
Okamoto, et al., "Glycosidation of Sialic Acid"
Cooper David K. C.
Good A. Heather
Malcolm Andrew J.
Alberta Research Council
Saunders David
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