Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2006-08-29
2006-08-29
Prats, Francisco C. (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S015000, C435S018000
Reexamination Certificate
active
07097968
ABSTRACT:
This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion reaction to form a Hcy conversion product and a Hcy co-substrate conversion product; and assessing the Hcy co-substrate conversion product to determine the presence, absence and/or amount of the Hcy in the sample. A kit for assaying homocysteine based on the same principle is also provided.
REFERENCES:
patent: 4981801 (1991-01-01), Suzuki et al.
patent: 5631127 (1997-05-01), Sundrehagen
patent: 5827645 (1998-10-01), Sundrehagen
patent: 5854023 (1998-12-01), Hillman et al.
patent: 5861294 (1999-01-01), Cowart et al.
patent: 5885767 (1999-03-01), Rozzell, Jr.
patent: 5958717 (1999-09-01), Sundrehagen
patent: 5985540 (1999-11-01), Tan et al.
patent: 6063581 (2000-05-01), Sundrehagen
patent: 6376210 (2002-04-01), Yuan
patent: 6436658 (2002-08-01), Seman
patent: 6610504 (2003-08-01), Yuan
patent: 6664073 (2003-12-01), Kawasaki et al.
patent: 6686172 (2004-02-01), Matsuyama et al.
patent: 2002/0119507 (2002-08-01), Kishimoto et al.
patent: 2002/0123088 (2002-09-01), Matsuyama et al.
patent: 2003/0138872 (2003-07-01), Kawasaki et al.
patent: 1560610 (2005-01-01), None
patent: WO-00/40973 (2000-07-01), None
patent: WO-00/77244 (2000-12-01), None
patent: WO-01/02600 (2001-01-01), None
patent: WO-03/040694 (2003-05-01), None
patent: WO 03/060478 (2003-07-01), None
Nelson, DL et al. Lehninger Principles of Biochemistry, 3rd edition. Worth Publishers. 2000. pp. 640-642.
Shapiro, SK. S-adenosylmethionine:L-homocysteine S-methyltransferase (Saccharomyces cerevisiae). Methods Enzymol. 1971. 17(Pt. B): 400-405.
Chagoya de Sanchez, V et al. 24-hour changes of S-adenosylmethionine, S-adenosylhomocysteine adenosine and their metabolizing enzymes in rat liver: possible physiological significance in phospholipid methylation. Int. J. Biochem. 1991. 23(12):1439-1443.
Kuchino, Y et al. Deficiency of S-adenosylmethionine-homocysteine methyltransferase activity in hepatoma cells. Cancer Research. 1977. 37: 206-208.
Araki, et al., J. Chromatog., 422:43-52 (1987).
Ballal, et al., Cleveland Clinic Journal of Medicine, 64:543-549 (1997).
Boers, et al., J. Inher. Metab. Dis., 20:301-306 (1997).
Boushey, et al., JAMA, 274:1049-1057 (1995).
Cornell and Riscoe, Biochim. Biophys. Acta, 1396(1):8-14 (1998).
Coulter-Karis and Hershfield, Ann. Hum. Genet., 53(2):169-175 (1989).
Diaz-Arrastia, et al., Arch. Neurol., 55:1407-1408 (1998).
Ducloux, et al., Nephrol. Dial. Transplantl, 13:2890-2893 (1998).
Foody, et al., Clinician Reviews, 8:203-210 (1998).
Frantzen, et al., Clinical Chemsitry 44:2, 311-316 (1998).
Gore, Int. J. Biochem., 13(8):879-86 (1981).
Hornberger, et al., American J. of Public Health, 88:61-67 (1998).
Jacobsen, et al., Clin. Chem., 44:2238-2239 (1998).
Lai, et al., Mol. Cell. Biol., 17(5):2413-24 (1997).
Mansoor, et al., Anal. BioChem., 200:218-229 (1992).
Matsuyama, et al., Clinical Chemistry, 47:2155-2156 (2001).
McNalley et al., Biochem. Biophys. Res. Commun. 231:645-650 (1997).
Moghadasian, et al., Arch. Intern. Med., 157:2299-2307 (1997).
Perez-de la Mora et al., Anal. Biochem., 180(2):248-52 (1989).
Perry, “Homocystinuria” in Nyhan W.L. ed., Heritable disorders of amino acid metabolism. New York, John Wiley & Sons, pp. 395-428 (1974).
Refsum, et al., Annu. Rev. Medicine, 49:31-62 (1998).
Saksela and Raivio, Biochem. J., 315(1):235-9 (1996).
Scott, et al., “The etiology of neural tube defects” in Graham, I., Refsum, H., Rosenberg, I.H., and Ureland P.M. ed. “Homocysteine metabolism: from basic science to clinical medicine” Kluwer Academic Publishers, Boston, pp. 133-136 (1995).
Shapiro, Biochim. Biophys. Acta. 29:405-9 (1958).
Shapiro et al., J. Biol. Chem., 239(5):1551-6 (1964).
Sigma-Aldrich catalog No. A5168.
Sigma-Aldrich catalog No. 01898.
Sigma-Aldrich catalog No. A9876.
Sigma-Aldrich catalog No. A1030.
Sigma-Aldrich catalog No. BCR647.
Sigma-Aldrich catalog No. 59023.
Sigma-Aldrich catalog No. 61311.
Sigma-Aldrich catalog No. 61306.
Sigma-Aldrich catalog No. K4388.
Sigma-Aldrich catalog No. P1903.
Sigma-Aldrich catalog No. P5788.
Sigma-Aldrich catalog No. 83330.
Singh et al., Eur. J. Biochem. 241:564-571 (1996).
Stabler, et al., J. Clin. Invest., 81:466-474 (1988).
Stehouwer, et al., Kidney International, 55:308-314 (1999).
Stein, et al., Arch. Intern. Med., 158:1301-1306 (1998).
Tan et al., Clinical Chemistry, 49:1029-1030 (2003).
Thanbichler et al., J. Bacteriol., 181(2):662-5 (1999).
Thomas et al., J Biol. Chem., 275(52):40718-24 (2000).
Ueland, et al., J. Lab. Clin. Med., 114:473-501 (1989).
Ueland, et al., Clin. Chem., 39:1764-1779 (1993).
International Search Report for PCT/US2004/022218, mailed on Jan. 7, 2005, 4 pages.
Complaint For Patent Infringement And Unfair Competition And Demand For Jury Trial, filed Oct. 9, 2001.
First Amended Complaint For Patent Infringement And Demand For Jury Trial, filed Dec. 19, 2001.
Answer To Amended Complaint And Counterclaim; Jury Demand, filed Jan. 8, 2002.
Plaintiff Axis-Shield ASA's Early Neutral Evaluation Conference Settlement Brief, filed Mar. 11, 2002.
Stipulation For Joint Dismissal Without Prejudice Of Complaint And Counter-Claim; [Proposed] Order, filed Mar. 22, 2002.
Complaint For Declaratory Relief, filed Oct. 11, 2005.
Answer And Counterclaim And Of Axis-Shield ASA, filed Oct. 27, 2005.
General Atomics' Reply To Counterclaim, filed Nov. 16, 2005.
Reply And Counterclaim Of Carolina Liquid Chemistries Corporation, filed Nov. 16, 2005.
Answer To Counterclaim Of Carolina Liquid Chemistries Corporation, filed Nov. 17, 2005.
Notice of Opposition to EP Patent 0 726 322, filed Jan. 16, 2004.
Patentee's Response to the Notices of Opposition, filed Oct. 1, 2004.
Response to Patentee's letter dated Oct. 1, 2004, filed Jul. 11, 2005.
Tanaka et al., Analytical Letters (1981) 14:111-118.
Selim and Greenberg, JBC (1958) 234:1474-1480.
Kashiwamata et al., Biochim. Biophys. Acta (1970) 212:488-500.
Binkley, JBC (1951) 101:531-534.
Shimizu et al., Biotechnol. Appl. Biochem. (1986) 8:153-159.
Porter et al., JBC (1991) 32:21616-21625.
Trewyn and Kerr, Journal of Biochemical and Biophysical Methods (1981) 4:299-307.
Loughlin et al., JBC (1964) 239:2888-2895.
Graham, Trends Cardiovasc. Med. (1991) 1:244-249.
Garras et al., Analytical Biochem. (1991) 199:112-118.
Frisell et al., JBC (1953) 207:709-716.
Sullivan and Hess, JBC (1936) 116:221-233.
EC4.2.1.22, www.chem.qmul.ac.uk/iubmb/enzyme/EC4/2/1/22.html.
Yamaguchi and Hosokawa, Methods in Enzymology (1987) 143:395-403.
Kotb and Kredich, J. Biol. Chem. (1985) 260(7):3923-30.
Tanaka et al., J. Applied Biochem. (1980) 2:439-444.
Bruton and Cox, Eur. J. Biochem. (1979) 100:301-308.
Homogeneous Enzymic Homocysteine Reagent package insert from Carolina Liquid Chemistries.
Datta Abhijit
Dou Chao
Yuan Chong-Sheng
Fernandez Susan E.
General Atomics
Prats Francisco C.
LandOfFree
Methods and compositions for assaying homocysteine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for assaying homocysteine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for assaying homocysteine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3637908