Methods and compositions for alleviating stuttering

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07858638

ABSTRACT:
Methods of treating stuttering include treating people with gamma-aminobutyric acid (GABA) receptor modulators, including cyclopyrrolones. A second active agent may be used with GABA receptor modulators. Active enantiomers, active metabolites, and pharmaceutically acceptable salts of gamma-aminobutyric acid receptor modulators, including cyclopyrrolones, are acceptable components of the compositions. The cyclopyrrolone class of modulators includes pagoclone, suriclone, zopiclone, 2-(7-chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one, 2-(7-chloro-2-naphthyridin-1,8-yl)isoindolin-1-yl-4-acetamidobutyrate, and 2-(7-chloro-1,8-naphthyridin-2yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone.

REFERENCES:
patent: 4401663 (1983-08-01), Buckwalter et al.
patent: 4788055 (1988-11-01), Fischer et al.
patent: 4816264 (1989-03-01), Phillips et al.
patent: 4828836 (1989-05-01), Elger et al.
patent: 4834965 (1989-05-01), Martani et al.
patent: 4834985 (1989-05-01), Elger et al.
patent: 4960779 (1990-10-01), Bourzat et al.
patent: 4996047 (1991-02-01), Kelleher et al.
patent: 5071646 (1991-12-01), Malkowska et al.
patent: 5133974 (1992-07-01), Paradissis et al.
patent: 5494915 (1996-02-01), Barreau et al.
patent: 5599936 (1997-02-01), Barreau et al.
patent: 5676831 (1997-10-01), Barreau et al.
patent: 9800727 (1998-05-01), None
Supprain et al., American Journal of Psychiatry, 1991, 156:10, 1663-1664.
Brady, J Clin Psychopharmacology, 1998;18(1):50-54.
Brady et al. 1991 “The Pharmacology of Stuttering: A Critical Review” Am J Psychiatry 148:1309-1316.
Wells et al. 1971 “Control Trial of the Treatment of 36 Stutterers” Brit. J. Psychiat. 119: 603-4.
Rentschler et al. 1984 “The Onset of Stuttering Following Drug Overdose” J. Fluency Disord. 9: 265-284.
Brewerton et al. 1996 “Stuttering With Sertaline” J Clin Psychiatry 57(2):90-1.
Vink et al. 1992 “Clonidine and stuttering” Am J. Psychiatry 149(5):717-8.
Costa 1992 “Antidepressants and the treatment of stuttering” Am J Psychiatry 149(9):1281.
Christensen et al. 1996 “A Case of Sertraline-Induced Stuttering” J Clin Psychopharmacol 16(1): 92-93.
Makela et al. 1996 “Reply [to Christensen et al.]” J Clin Psychopharmacol 16(1):93.
Brady 1992 “Dr. Brady Replies [to Vink et al.]” Am J. Psychiatry 149(56):718.
Brady 1992 “Dr. Brady Replies [to Costa]” Am J. Psychiatry 149(9):1281.
Stager et al. 1995 “Fluency Changes in Persons Who Stutter Following a Double Blind Trial of Clomipramine and Desipramine” J Speech Hear Res. 38:516-25.
Schreiber et al 1997 “Paroxetine for secondary stuttering: further interaction of serotonin and dopamine”J Nerv Ment Dis. 185(7):465-7.
Fernandez et al. 1995 “Clinical Pharmacokinetics of Zopiclone”; Clin Pharmacokinet, 29(6): 431-41.
Doble et al. 1993 “RP 59037 and RP 60503: Anxiolytic Cyclopyrrolone Derivatives with Low Sedative Potential. Interaction with the γ-Aminobutyric Acidimg id="CUSTOM-CHARACTER-00001" he="3.13mm" wi="1.78mm" file="US07858638-20101228-P00001.TIF" alt="custom character" img-content="character" img-format="tif" ?/Benzodiazepine Receptor Complex and Behavioral Effects in the Rodent” J Pharmacol Exp Ther. 266(3):1213-26.
Korpi et al. 1997 “GABAimg id="CUSTOM-CHARACTER-00002" he="3.13mm" wi="1.78mm" file="US07858638-20101228-P00001.TIF" alt="custom character" img-content="character" img-format="tif" ?-receptor Subtypes: Clinical Efficacy and Selectivity of Benzodiazepine Site Ligands” Annals Med 29:275-282; Erratum 1997 Annals Med 29: 275-82.
Kiziltan et al. 1996 “Stuttering May Be a Type of Action Dystonia” Movement Disorders 11(3): 278-282.
Swinyard 1990 “Sedatives and Hypnotics”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co., Easton, PA, pp. 1057-1071.
Di Santo 1990 “Bioavailability and Bioequivalency Testing”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co., Easton, PA, pp. 1451-1458.
Vadas1990 “Stability of Pharmaceutical Products”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co.,Easton, PA, pp. 1504-1512.
Naim 1990 “Solutions, Emulsions, Suspensions and Extracts”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co., Easton, PA, pp. 1519-1544.
Avis 1990 “Parenteral Preparations”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co., Easton, PA, pp. 1545-1569.
O'Connor et al. 1990 “Powders”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co., Easton, PA, pp. 1615-1632.
Rudnic et al. 1990 “Oral Solid Dosage Forms”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co., Easton, PA, pp. 1633-1665.
Porter 1990 “Coating of Pharmaceutical Dosage Forms”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co., Easton, PA, pp. 1666-1675.
Longer et al. 1990 “Sustained-Release Drug Delivery Systems”, Remington's Pharmaceutical Sciences, Gennaro, A.R., 18th Edition, Mack Publishing Co., Easton, PA, pp. 1676-1693.
Brady 1998 “Drug-Induced Stuttering: A Review of the Literature”, J. Clin. Psychopharmacol. 18(1):50-4.
Elliott et al. 1985 “A Case Report of Alprazolam Induced Stuttering”, J. Clin. Psychopharmacol 5(3):159-60.

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