Methods and compositions employing unique mixtures of polar and

Details Methods and compositions employing unique mixtures of polar and Methods and compositions employing unique mixtures of polar and

1988-11-02

1991-08-27

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 77, 514171, 514182, 514925, A61K 31685

Patent

active

050433296

ABSTRACT:
Disclosed are compositions composed of unique mixtures of phospholipids and neutral lipids and methods of employing such compositions to treat the luminal lining of the gastrointestinal tract in the prevention or treatment of ulcerogenic processes such as peptic ulcer disease and inflammatory bowel disease. Compositions including mixtures of saturated or unsaturated phospholipids, together with saturated or unsaturated triglycerides and/or sterols, are shown to provide a surprising ulcer protective efficacy in experimental models. Further enhancement of activity is found upon the addition of a polyvalent cation or antioxidant to the various lipid mixtures.

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