Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1990-05-14
1991-07-09
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 855, C07K 1526, A61K 3766
Patent
active
050307169
ABSTRACT:
The present disclosure is directed to improved pharmaceutical compositions employing interferon-gamma which have been treated to remove interferon-gamma inhibitory activity associated with such preparations. In addition, the present disclosure details treatment protocols, including the elevation of patient body temperature and the use of combined or sequential interferon-gamma treatments, to enhance interferon-gamma efficacy and reduce the resistance associated with interferon-alpha and/or beta therapy.
REFERENCES:
Lundblad, et al., "Chemical Reagents for Protein Modifications", vol. 1, CRC Press, Inc., Boca Raton, Fl., pp. 55-61.
Baker R. Keith
Board of Regents , The University of Texas System
Moskowitz Margaret
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