Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2009-06-15
2011-11-15
Whiteman, Brian (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
Reexamination Certificate
active
08058255
ABSTRACT:
The present invention concerns an isolated siRNA of from about 5 to about 20 nucleotides that mediates RNA interference. Also disclosed are methods of reducing expression of a target gene in a cell comprising obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 basepairs in length; and delivering the siRNA into the cell. The siRNAs can be chemically synthesized RNA or an analog of a naturally occurring RNA.
REFERENCES:
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4786600 (1988-11-01), Kramer et al.
patent: 4828979 (1989-05-01), Kievan et al.
patent: 4849513 (1989-07-01), Smith et al.
patent: 4910300 (1990-03-01), Urdea et al.
patent: 4952496 (1990-08-01), Studier et al.
patent: 5026645 (1991-06-01), Kotani et al.
patent: 5037735 (1991-08-01), Khanna et al.
patent: 5102802 (1992-04-01), McAllister
patent: 5241060 (1993-08-01), Engelhardt et al.
patent: 5489527 (1996-02-01), Wilson
patent: 5573913 (1996-11-01), Rosemeyer et al.
patent: 5591601 (1997-01-01), Wagner et al.
patent: RE35443 (1997-02-01), DeFrancesco et al.
patent: 5624803 (1997-04-01), Noonberg et al.
patent: 5643768 (1997-07-01), Kawasaki
patent: 5645897 (1997-07-01), Andra
patent: 5705629 (1998-01-01), Bhongle
patent: 5728525 (1998-03-01), Conrad
patent: 5734039 (1998-03-01), Calabretta
patent: 5776905 (1998-07-01), Gibbons et al.
patent: 5795715 (1998-08-01), Livache et al.
patent: 5824528 (1998-10-01), Studier et al.
patent: 5869320 (1999-02-01), Studier et al.
patent: 5889136 (1999-03-01), Scaringe et al.
patent: 5891681 (1999-04-01), Mallet et al.
patent: 5898031 (1999-04-01), Crooke
patent: 5998135 (1999-12-01), Rabbani et al.
patent: 5998203 (1999-12-01), Matulic-Adamic et al.
patent: 6005087 (1999-12-01), Cook et al.
patent: 6083482 (2000-07-01), Wang
patent: 6107094 (2000-08-01), Crooke
patent: 6114152 (2000-09-01), Serafini et al.
patent: 6262252 (2001-07-01), Wolff et al.
patent: 6268490 (2001-07-01), Imanishi et al.
patent: 6372433 (2002-04-01), Baker et al.
patent: 6376179 (2002-04-01), Laayoun
patent: 6455292 (2002-09-01), Shu et al.
patent: 6506559 (2003-01-01), Fire et al.
patent: 6525191 (2003-02-01), Ramasamy
patent: 6573099 (2003-06-01), Graham
patent: 6639059 (2003-10-01), Kochkine et al.
patent: 6670461 (2003-12-01), Wengel et al.
patent: 6673611 (2004-01-01), Thompson et al.
patent: 6734291 (2004-05-01), Kochkine et al.
patent: 6770748 (2004-08-01), Imanishi et al.
patent: 6794499 (2004-09-01), Wengel et al.
patent: 6849726 (2005-02-01), Usman et al.
patent: 7022828 (2006-04-01), McSwiggen et al.
patent: 7034133 (2006-04-01), Wengel et al.
patent: 7053207 (2006-05-01), Wengel
patent: 7056704 (2006-06-01), Tuschl et al.
patent: 7060809 (2006-06-01), Wengel et al.
patent: 7074558 (2006-07-01), Haydock et al.
patent: 7078196 (2006-07-01), Tuschl et al.
patent: 7084125 (2006-08-01), Wengel
patent: 7176304 (2007-02-01), McSwiggen et al.
patent: 7790878 (2010-09-01), Barik
patent: 2002/0086356 (2002-07-01), Tuschl et al.
patent: 2002/0162126 (2002-10-01), Beach et al.
patent: 2002/0173478 (2002-11-01), Gewirtz
patent: 2002/0197641 (2002-12-01), Minc-Golomb
patent: 2003/0009295 (2003-01-01), Markowitz et al.
patent: 2003/0044941 (2003-03-01), Crooke
patent: 2003/0077609 (2003-04-01), Jakobsen et al.
patent: 2003/0108923 (2003-06-01), Tuschl et al.
patent: 2003/0119104 (2003-06-01), Perkins et al.
patent: 2003/0153519 (2003-08-01), Kay et al.
patent: 2003/0166282 (2003-09-01), Brown et al.
patent: 2003/0203868 (2003-10-01), Bushman et al.
patent: 2003/0224377 (2003-12-01), Wengel et al.
patent: 2003/0224432 (2003-12-01), Myers et al.
patent: 2004/0014108 (2004-01-01), Eldrup et al.
patent: 2004/0029275 (2004-02-01), Brown et al.
patent: 2004/0033602 (2004-02-01), Ford et al.
patent: 2004/0038921 (2004-02-01), Kreutzer et al.
patent: 2004/0053875 (2004-03-01), Kreutzer et al.
patent: 2004/0067882 (2004-04-01), Alsobrook, II et al.
patent: 2004/0072779 (2004-04-01), Kreutzer et al.
patent: 2004/0091926 (2004-05-01), Liu et al.
patent: 2004/0096843 (2004-05-01), Rossi et al.
patent: 2004/0102408 (2004-05-01), Kreutzer et al.
patent: 2004/0147022 (2004-07-01), Baker et al.
patent: 2004/0171031 (2004-09-01), Baker et al.
patent: 2004/0171033 (2004-09-01), Baker et al.
patent: 2004/0171570 (2004-09-01), Allerson et al.
patent: 2004/0175703 (2004-09-01), Kreutzer et al.
patent: 2004/0198640 (2004-10-01), Leake et al.
patent: 2004/0203024 (2004-10-01), Baker et al.
patent: 2004/0203145 (2004-10-01), Zamore et al.
patent: 2004/0219565 (2004-11-01), Kauppinen et al.
patent: 2004/0229266 (2004-11-01), Tuschl et al.
patent: 2004/0248094 (2004-12-01), Ford et al.
patent: 2004/0248299 (2004-12-01), Jayasena et al.
patent: 2004/0259097 (2004-12-01), De Backer et al.
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2005/0020521 (2005-01-01), Rana
patent: 2005/0020525 (2005-01-01), McSwiggen et al.
patent: 2005/0026160 (2005-02-01), Allerson et al.
patent: 2005/0058982 (2005-03-01), Han et al.
patent: 2005/0080246 (2005-04-01), Allerson et al.
patent: 2005/0100907 (2005-05-01), Kreutzer et al.
patent: 2005/0119214 (2005-06-01), Manoharan et al.
patent: 2005/0176018 (2005-08-01), Thompson et al.
patent: 2005/0214823 (2005-09-01), Blume et al.
patent: 2005/0223427 (2005-10-01), Leake et al.
patent: 2005/0244858 (2005-11-01), Rossi et al.
patent: 2005/0256071 (2005-11-01), Davis
patent: 2005/0287566 (2005-12-01), Wengel
patent: 2006/0134787 (2006-06-01), Zamore et al.
patent: 2006/0142228 (2006-06-01), Ford et al.
patent: 2006/0166910 (2006-07-01), Tuschl et al.
patent: 2006/0217334 (2006-09-01), McSwiggen et al.
patent: 2006/0217335 (2006-09-01), McSwiggen et al.
patent: 2006/0217336 (2006-09-01), McSwiggen et al.
patent: 2006/0217337 (2006-09-01), McSwiggen et al.
patent: 2006/0247428 (2006-11-01), McSwiggen et al.
patent: 2006/0247429 (2006-11-01), McSwiggen et al.
patent: 2006/0276635 (2006-12-01), McSwiggen et al.
patent: 2006/0287266 (2006-12-01), McSwiggen et al.
patent: 2006/0293271 (2006-12-01), McSwiggen et al.
patent: 2007/0004663 (2007-01-01), McSwiggen et al.
patent: 2007/0004665 (2007-01-01), McSwiggen et al.
patent: 2007/0004667 (2007-01-01), McSwiggen et al.
patent: 2007/0111228 (2007-05-01), Jayasena et al.
patent: 2007/0265438 (2007-11-01), Khvorova et al.
patent: 2008/0086002 (2008-04-01), Khvorova et al.
patent: 0178863 (1985-10-01), None
patent: 0266032 (1987-08-01), None
patent: WO 88/10315 (1988-06-01), None
patent: WO 91/02818 (1991-03-01), None
patent: WO 91/05866 (1991-05-01), None
patent: WO 99/32619 (1998-12-01), None
patent: WO 00/01846 (2000-01-01), None
patent: WO 00/44914 (2000-08-01), None
patent: WO 01/68836 (2001-03-01), None
patent: WO 01/36646 (2001-05-01), None
patent: WO 01/75164 (2001-10-01), None
patent: WO 01/96584 (2001-12-01), None
patent: WO 02/44321 (2002-06-01), None
patent: WO 03/070918 (2003-08-01), None
patent: WO 03/100059 (2003-12-01), None
patent: WO 03/102214 (2003-12-01), None
patent: WO 03/106630 (2003-12-01), None
patent: WO 03/106631 (2003-12-01), None
patent: WO 2005/035004 (2005-04-01), None
Kits for Labeling DNA, BioDirectory'98, Amersham Pharmacia Biotech, p. 136, 1998.
OligofectAMINE Reagent product information, Cat. No. 12252-01 Invitrogen Life Reagent, Reviewed Aug. 23, 2001.
Amarzguioui et al., “Tolerance for Mutations and Chemical Modification in a siRNA,”Nucleic Acids Research, 31(2):589-595, 2003.
Ambion Inc., “RNA Interference and Gene Silencing—an Update,” printed from http://www.ambion.com/hottopics/RNAi/rnai—jun2001.html, Jun. 2001.
Ambion Inc., “Products for RNA Structure/Function Analysis,”Ambion TechNotes, 8(5):1-3, Nov. 2001.
Ambion Inc. , “Silencer™siRNA Construction Kit—Protocol—Large Scale Synthesis and Purification of siRNAs,” Catalog #1620, Sep. 2002.
Ambion Inc., “Design and testing of siRNAs,”Ambion TechNotes, 9(1):4, Feb. 2002.
Ambion Inc., “RNA Interface in Mammalian Cell Culture: Desig
Ford Lance P.
Krebs Joseph
Applied Biosystems LLC
Whiteman Brian
LandOfFree
Methods and compositions concerning siRNA's as mediators of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions concerning siRNA's as mediators of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions concerning siRNA's as mediators of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4291124