Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Reexamination Certificate
2004-01-09
2010-06-15
Lam, Ann Y (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Reexamination Certificate
active
07736909
ABSTRACT:
The present invention relates to methods and compositions for detecting a substance using mixed or multiple element capture agents (MECA). The affinity of a MECA for a target is produced by the concomitant binding of at least two low to moderate affinity capture agents providing a high affinity interaction with a capture target.
REFERENCES:
patent: 4789628 (1988-12-01), Nayak
patent: 5011771 (1991-04-01), Bellet et al.
patent: 5149626 (1992-09-01), Fleming
patent: 5705614 (1998-01-01), Ring
patent: 6153596 (2000-11-01), Liotta et al.
patent: 6197599 (2001-03-01), Chin et al.
patent: 6297059 (2001-10-01), Song et al.
patent: 6306643 (2001-10-01), Gentalen et al.
patent: 6344330 (2002-02-01), Ellman et al.
patent: 6344334 (2002-02-01), Ellman et al.
patent: 6365418 (2002-04-01), Wagner et al.
patent: 6406921 (2002-06-01), Wagner et al.
patent: 6465183 (2002-10-01), Wolber
patent: 6465430 (2002-10-01), Dower et al.
patent: 6800728 (2004-10-01), Schwartz
patent: 7091046 (2006-08-01), Monforte
patent: 7504364 (2009-03-01), Carlson
patent: 7504365 (2009-03-01), Carlson
patent: 2002/0006620 (2002-01-01), Short
patent: 2002/0018749 (2002-02-01), Hudson et al.
patent: 2002/0022227 (2002-02-01), Short
patent: 2002/0098493 (2002-07-01), Nathan
patent: 2002/0137106 (2002-09-01), Leung et al.
patent: 2004/0171068 (2004-09-01), Wehland et al.
patent: 0268296 (1988-05-01), None
patent: 0317804 (1989-05-01), None
patent: 0491362 (1992-06-01), None
patent: 0586618 (1997-07-01), None
patent: 0818467 (1998-01-01), None
patent: WO 01/69258 (2001-09-01), None
patent: WO 02/31510 (2002-04-01), None
patent: WO 02/063299 (2002-08-01), None
patent: WO 03/074990 (2003-09-01), None
Bachhawat-Sikder and Kodadek, “Mixed-element capture agents: a simple strategy for the construction of synthetic, high-affinity protein capture ligands,”J. Am. Chem. Soc., 125:9550-9551, 2003.
Burkoth et al., “Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly,”Chem. Biol., 9:647-654, 2002.
Cussac et al., “A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity,”FASEB J., 13:31-38, 1999.
Fancy and Kodadek, “Chemistry for the analysis of protein-protein interactions: rapid and efficient cross-linking triggered by long wavelength light,”Proc. Natl. Acad. Sci., USA, 96:6020-6024, 1999.
Figliozzi et al., “Synthesis of N-substituted glycine peptoid libraries,”Methods Enzymol., 267:437-447, 1996.
Hajkuk et al., “Discovering high-affinity ligands for proteins,”Science, 278(5337):497-499, 1997.
Han and Kodadek, “Peptides selected to bind the Gal80 repressor are potent transcriptional activation domains in yeast,”J. Biol. Chem., 275(20):14979-14984, 2000.
Kiessling et al., “Synthetic multivalent ligands in the exploration of cell-surface interactions,”Curr. Opin. Chem. Biol., 4:696-703, 2000.
Kirshenbaum et al., “Sequence-specific polypeptoids: a diverse family of heteropolymers with stable secondary structure,”Proc. Natl. Acad. Sci., USA, 95:4303-4308, 1998.
Kitov et al., “Shiga-like toxins are neutralized by tailored multavalent carbohydrate ligands,”Nature, 403:669-672, 2000.
Kodadek, “Protein microarrays: prospects and problems,”Chem. Biol., 8:105-115, 2001.
Kodadek, “Development of protein-detecting microarrays and related devices,”Trends Biochem. Sci., 27(6):295-300, 2002.
Koehler et al., “Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis,”J. Amer. Chem. Soc., 125:8420-8421, 2003.
Kuruvilla et al., “Dissecting glucose signaling with diversity-oriented synthesis and small-molecule microarrays,”Nature, 416:653-657, 2002.
Ladbury et al., “Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.,”Proc. Natl. Acad. Sci., USA, 92:3199-3203, 1995.
Maly et al., “Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors,”Proc. Natl. Acad. Sci., USA, 97:2419-2424, 2000.
Melcher and Xu,EMBO J., “Gal80-Gal80 interaction on adjacent Gal4p binding sites is required for complete GAL gene repression,” 20:841-851, 2001.
Merritt et al., “Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin andE. coliheat-labile enterotoxin,”J. Amer. Chem. Soc., 124:8818-8824, 2002.
Olejniczak et al., “Stromelysin inhibitors designed from weakly bound fragments: effects of linking and cooperativity,”J. Amer. Chem. Soc., 119:5828-5832, 1997.
Oliver et al., “Multiplexed Analysis of Human Cytokines by Use of the FlowMetrix System,”Clinical Chemistry, 44:2057-2060, 1998.
Schreiber, “Target-oriented and diversity-oriented organic synthesis in drug discovery,”Science, 287(5460), 1964-1969, 2000.
Shuker et al., “Discovering high-affinity ligands for proteins: SAR by NMR,”Science, 274:1531-1534, 1996.
Stoll et al., “Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53,”Biochemistry, 40:336-344, 2001.
Terskikh et al., “‘Peptabody’: a new type of high avidity binding protein,”Proc. Natl. Acad. Sci., USA, 94:1663-1668, 1997.
Thoma et al., “Nanomolar E-selectin inhibitors: 700-fold potentiation of affinity by multivalent ligand presentation,”J. Amer. Chem. Soc., 123:10113-10114, 2001.
Vignali, “Multiplexed particle-based flow cytometric assays,”J. of Immunol. Methods, 243:243-255, 2000.
Woodbury and Vinton., “Methods of screening combinatorial libraries using immobilized or restrained receptors,”J. Chromatogr B Biomed. Sci. Appl., 725:113-137, 1999.
Board of Regents the University of Texas System
Fulbright & Jaworski L.L.P.
Lam Ann Y
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